Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ DOI: doi:10.1002/advs.202303411 Pubmed: 37759382 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w88
Q-score: 0.59
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Sep363856-bound taar1-gs complex (Complex from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w8b
Q-score: 0.55
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Cryo-em structure of sep-363856 bounded serotonin 1a (5-ht1a) receptor-gi protein complex (Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of hDisp1NNN-3C
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7e2g
Q-score: 0.471
Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X
Nat Commun (2021) 12 pp. 6966-6966 [ DOI: doi:10.1038/s41467-021-27257-w Pubmed: 34845226 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hdisp1nnn-3c (150 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein dispatched homolog 1,protein dispatched homolog 1 (169 kDa, Protein from Homo sapiens)
Cryo-EM structure of hDisp1NNN-3C-Cleavage
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 7e2h
Q-score: 0.464
Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X
Nat Commun (2021) 12 pp. 6966-6966 [ DOI: doi:10.1038/s41467-021-27257-w Pubmed: 34845226 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein dispatched homolog 1 (140 kDa, Protein from Homo sapiens)
- Protein dispatched homolog 1 (29 kDa, Protein from Homo sapiens)
- Hdisp1nnn-3c (150 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of hDisp1NNN-ShhN
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7e2i
Q-score: 0.375
Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X
Nat Commun (2021) 12 pp. 6966-6966 [ DOI: doi:10.1038/s41467-021-27257-w Pubmed: 34845226 ]
- Hdisp1nnn-shhn (150 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein dispatched homolog 1 (171 kDa, Protein from Homo sapiens)
- Sonic hedgehog protein (49 kDa, Protein from Homo sapiens)
- Hdisp1nnn (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Shhn (Complex from Homo sapiens)
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7jv5
Q-score: 0.431
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- (1r)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (289 Da, Ligand)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7jvp
Q-score: 0.485
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- (1r)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (317 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7jvq
Q-score: 0.458
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- (6ar)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol (267 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Nanobody35 (14 kDa, Protein from synthetic construct)
- Engineered mini-gi protein alpha sub-unit (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6uy0
Q-score: 0.515
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.56451 Pubmed: 32458799 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) (170 kDa, Complex from Bos taurus)
- Multidrug resistance-associated protein 1 (172 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol (386 Da, Ligand)