Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8y69
Q-score: 0.391
To Be Published
- Mb52 (59 kDa, Protein from Camelus bactrianus)
- R-spondin-2 (11 kDa, Protein from Homo sapiens)
- Leucine-rich repeat-containing g-protein coupled receptor 4 (87 kDa, Protein from Homo sapiens)
- The di-heterotrimer complex of lgr4-rspo2-znrf3(delete ring domain) (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- E3 ubiquitin-protein ligase znrf3 (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo hTAAR1-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zsj
Q-score: 0.542
Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F
Cell Rep (2024) 43 pp. 114505-114505 [ DOI: doi:10.1016/j.celrep.2024.114505 Pubmed: 39002128 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- The apo htaar1-gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Soluble cytochrome b562,trace amine-associated receptor 1 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ DOI: doi:10.1002/advs.202303411 Pubmed: 37759382 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of bilirubin ditaurate (BDT) bound human ABC transporter ABCC2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8jxq
Q-score: 0.364
Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y
Nat Commun (2024) 15 pp. 1061-1061 [ DOI: doi:10.1038/s41467-024-45337-5 Pubmed: 38316776 ]
- Atp-binding cassette sub-family c member 2 (Cellular component from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-[3-[5-[(e)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-3-[3-oxidanylidene-3-(2-sulfoethylamino)propyl]-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoylamino]ethanesulfonic acid (798 Da, Ligand)
- Atp-binding cassette sub-family c member 2 (176 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w88
Q-score: 0.59
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Sep363856-bound taar1-gs complex (Complex from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w8b
Q-score: 0.55
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ Pubmed: 37935377 DOI: doi:10.1038/s41586-023-06775-1 ]
- Cryo-em structure of sep-363856 bounded serotonin 1a (5-ht1a) receptor-gi protein complex (Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7fdv
Q-score: 0.528
Xu D, Li Y, Yang F, Sun CR, Pan J, Wang L, Chen ZP, Fang SC, Yao X, Hou WT, Zhou CZ, Chen Y
Cell Rep (2022) 38 pp. 110298-110298 [ Pubmed: 35081353 DOI: doi:10.1016/j.celrep.2022.110298 ]
- The complex of human abcg1 with cholesterol and atp (152 kDa, Complex from Homo sapiens)
- [(e,2s,3r)-2-(hexadecanoylamino)-3-oxidanyl-octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate (703 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Atp-binding cassette sub-family g member 1 (75 kDa, Protein from Homo sapiens)
Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7vzb
Q-score: 0.429
Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ, Hou WT, Chen Y
Nat Commun (2022) 13 pp. 3299-3299 [ DOI: doi:10.1038/s41467-022-30974-5 Pubmed: 35676282 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human peroxisomal abcd1 (175 MDa, Cellular component from Caenorhabditis elegans)
- Peroxisomal membrane protein related,atp-binding cassette sub-family d member 1 (87 kDa, Protein from Homo sapiens)
- S-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate (1 kDa, Ligand)
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7jv5
Q-score: 0.431
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- (1r)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (289 Da, Ligand)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7jvp
Q-score: 0.485
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- (1r)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (317 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)