Structure of NET-Nisoxetine in outward-open state
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8yr2
Q-score: 0.47
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Nisoxetine (271 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(2r,3r,5s,6r)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (586 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7fiy
Q-score: 0.413
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the tirzepatide-bound human gipr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Tiezepatide (4 kDa, Protein from synthetic construct)
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vab
Q-score: 0.437
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Non-acylated_tirzepatide (4 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with non-acylated_tirzepatide and g protein (Complex from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Nonobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7fin
Q-score: 0.401
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with peptide 20 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Gamma-l-glutamic acid (147 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Peptide 20 (4 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7f16
Q-score: 0.415
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW
PNAS (2021) 118 [ Pubmed: 34353904 DOI: doi:10.1073/pnas.2101279118 ]
- Palmitic acid (256 Da, Ligand)
- Parathyroid hormone 2 receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Tuberoinfundibular peptide of 39 residues (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dur
Q-score: 0.273
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evm
Q-score: 0.481
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Glp-1 receptor (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7dty
Q-score: 0.436
Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW
eLife (2021) 10 [ DOI: doi:10.7554/eLife.68719 Pubmed: 34254582 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide (4 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with gip and g protein (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7dw9
Q-score: 0.551
Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y
Cell Res (2021) 31 pp. 929-931 [ DOI: doi:10.1038/s41422-021-00480-2 Pubmed: 33742150 ]
- Vasopressin v2 receptor (71 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of human v2 vasopressin receptor in complex with an gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Nanobody35 (15 kDa, Protein from synthetic construct)
- Cys-tyr-phe-gln-asn-cys-pro-arg-gly-nh2 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7duq
Q-score: 0.536
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Glucagon-like peptide 1 (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Cryo-em structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)