Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8xm6
Q-score: 0.435
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc transporter 1 (Complex from Homo sapiens)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xma
Q-score: 0.538
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc transporter 1 (Complex from Homo sapiens)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8xmf
Q-score: 0.393
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ Pubmed: 39390258 DOI: doi:10.1038/s44319-024-00287-3 ]
- Zinc ion (65 Da, Ligand)
- Zinc transporter 1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 8xmj
Q-score: 0.327
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ DOI: doi:10.1038/s44319-024-00287-3 Pubmed: 39390258 ]
- Zinc transporter 1 (Complex from Homo sapiens)
- Proton-coupled zinc antiporter slc30a1 (58 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8xn1
Q-score: 0.482
Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q
EMBO Rep (2024) 25 pp. 5006-5025 [ Pubmed: 39390258 DOI: doi:10.1038/s44319-024-00287-3 ]
- Zinc ion (65 Da, Ligand)
- Zinc transporter 3 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Probable proton-coupled zinc antiporter slc30a3 (42 kDa, Protein from Homo sapiens)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
Structure of NET-Nisoxetine in outward-open state
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8yr2
Q-score: 0.47
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Nisoxetine (271 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(2r,3r,5s,6r)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (586 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7fiy
Q-score: 0.413
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the tirzepatide-bound human gipr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Tiezepatide (4 kDa, Protein from synthetic construct)
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vab
Q-score: 0.437
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Non-acylated_tirzepatide (4 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with non-acylated_tirzepatide and g protein (Complex from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Nonobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7fin
Q-score: 0.401
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ Pubmed: 35217653 DOI: doi:10.1038/s41467-022-28683-0 ]
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with peptide 20 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Gamma-l-glutamic acid (147 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Peptide 20 (4 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7f16
Q-score: 0.415
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW
PNAS (2021) 118 [ Pubmed: 34353904 DOI: doi:10.1073/pnas.2101279118 ]
- Palmitic acid (256 Da, Ligand)
- Parathyroid hormone 2 receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Tuberoinfundibular peptide of 39 residues (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)