Structure of mouse Myomaker bound to Fab18G7 in detergent
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8t03
Q-score: 0.574
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Fab18g7 (Complex from Mus musculus)
- Mouse myomaker (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Complex of mouse myomaker and fab18g7 (Complex)
Structure of mouse Myomaker bound to Fab18G7 in nanodiscs
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8t04
Q-score: 0.528
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
- Fab18g7 (Complex from Mus musculus)
- Mouse myomaker (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Complex of mouse myomaker with fab18g7 in nanodiscs (Complex)
- Zinc ion (65 Da, Ligand)
Structure of Ciona Myomaker bound to Fab1A1
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8t05
Q-score: 0.497
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Myomaker (24 kDa, Protein from Ciona robusta)
- Fab1a1 (Complex from Mus musculus)
- 1a1 fab light chain (11 kDa, Protein from Mus musculus)
- Complex of ciona robusta myomaker with fab1a1 (Complex)
- Ciona robusta myomaker (Complex from Ciona robusta)
- Cholesterol (386 Da, Ligand)
- 1a1 fab heavy chain (13 kDa, Protein from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8djk
Q-score: 0.45
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
- Digitonin (1 kDa, Ligand)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8djm
Q-score: 0.468
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
- Digitonin (1 kDa, Ligand)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
Human PORCN in complex with Palmitoleoyl-CoA
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7ura
Q-score: 0.557
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ DOI: doi:10.1038/s41586-022-04952-2 Pubmed: 35831507 ]
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Digitonin (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{z})-hexadec-9-enethioate (1 kDa, Ligand)
- Oleic acid (282 Da, Ligand)
- 16:1 coa-bound human porcn (Complex)
- Zinc ion (65 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7urc
Q-score: 0.532
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ DOI: doi:10.1038/s41586-022-04952-2 Pubmed: 35831507 ]
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Digitonin (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Lgk974-bound human porcn (Complex)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7urd
Q-score: 0.569
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ DOI: doi:10.1038/s41586-022-04952-2 Pubmed: 35831507 ]
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of protein wnt-3a peptide (Complex)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Digitonin (1 kDa, Ligand)
- Cholesterol (386 Da, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Isoform 2 of protein wnt-3a peptide (2 kDa, Protein from Homo sapiens)
- Lgk974 and wnt3a peptide-bound human porcn (Complex)
The structure of human ABCG5/ABCG8 purified from mammalian cells
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7r8a
Q-score: 0.552
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Abcg1 transporter (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Fab 2c7 (Complex from Mus musculus)
The structure of human ABCG5/ABCG8 supplemented with cholesterol
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7r8b
Q-score: 0.533
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2110483118 Pubmed: 34404721 ]
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- Abcg1 transporter with cholesterol bound (Complex from Homo sapiens)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Fab 2c7 (Complex from Mus musculus)