CryoEM structure of NaDC1 with Citrate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w6c
Q-score: 0.631
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Structure of nadc1 in complex with citrate (Complex from Homo sapiens)
- Citric acid (192 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
CryoEM structure of NaDC1 in apo state
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8w6d
Q-score: 0.662
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Structure of nadc1 in apo state (Complex from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w6g
Q-score: 0.552
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nadc1 in complex with inhibitor n-(p-amylcinnamoyl)anthranilic acid (aca) (Complex from Homo sapiens)
- 2-[[(~{e})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid (337 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
NaS1 with sulfate - IN/IN state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w6h
Q-score: 0.567
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Sulfate ion (96 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
- Dimer of nas1 with sulfate in in/in state (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8w6o
Q-score: 0.58
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ Pubmed: 38552027 DOI: doi:10.1126/sciadv.adl3685 ]
- Sodium ion (22 Da, Ligand)
- Dimer of nas1 in in/in state (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7e1z
Q-score: 0.479
Guo Y, Zhang Y, Yan R, Huang B, Ye F, Wu L, Chi X, Shi Y, Zhou Q
Nat Commun (2022) 13 pp. 3957-3957 [ DOI: doi:10.1038/s41467-022-31602-y Pubmed: 35803952 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium/potassium-transporting atpase subunit alpha-1 (113 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium/potassium-transporting atpase subunit gamma (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Cryo em structure of a na+-bound na+,k+-atpase in the e1 state (Complex from Homo sapiens)
Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7e20
Q-score: 0.563
Guo Y, Zhang Y, Yan R, Huang B, Ye F, Wu L, Chi X, Shi Y, Zhou Q
Nat Commun (2022) 13 pp. 3957-3957 [ DOI: doi:10.1038/s41467-022-31602-y Pubmed: 35803952 ]
- Water (18 Da, Ligand)
- Sodium/potassium-transporting atpase subunit alpha-1 (113 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cryo em structure of a k+-bound na+,k+-atpase in the e2 state (Complex from Homo sapiens)
- Sodium/potassium-transporting atpase subunit gamma (7 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7e21
Q-score: 0.535
Guo Y, Zhang Y, Yan R, Huang B, Ye F, Wu L, Chi X, Shi Y, Zhou Q
Nat Commun (2022) 13 pp. 3957-3957 [ DOI: doi:10.1038/s41467-022-31602-y Pubmed: 35803952 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium/potassium-transporting atpase subunit alpha-1 (113 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium/potassium-transporting atpase subunit gamma (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo em structure of a na+-bound na+,k+-atpase in the e1 state with atp-gamma-s (Complex from Homo sapiens)
- Sodium/potassium-transporting atpase subunit beta-1 (35 kDa, Protein from Homo sapiens)
cryo EM map of the LAT1-4F2hc bound with JX-075
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsk
Q-score: 0.541
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ DOI: doi:10.1038/s41421-021-00247-4 Pubmed: 33758168 ]
- Water (18 Da, Ligand)
- (2~{s})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (347 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lat1-4f2hc bound with jx-075 (Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
cryo EM map of the LAT1-4F2hc bound with JX-078
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsl
Q-score: 0.539
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ DOI: doi:10.1038/s41421-021-00247-4 Pubmed: 33758168 ]
- Water (18 Da, Ligand)
- (2~{s})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (373 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Lat1-4f2hc bound with jx-078 (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)