cryo EM map of the LAT1-4F2hc bound with JX-075
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsk
Q-score: 0.541
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Water (18 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2~{s})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (347 Da, Ligand)
- Lat1-4f2hc bound with jx-075 (Complex from Homo sapiens)
cryo EM map of the LAT1-4F2hc bound with JX-078
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dsl
Q-score: 0.539
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Lat1-4f2hc bound with jx-078 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (373 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
cryo EM map of the LAT1-4F2hc bound with JX-119
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7dsn
Q-score: 0.53
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Lat1-4f2hc bound with jx-119 (Complex from Homo sapiens)
- (2~{s})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{h}-naphthalene-2-carboxylic acid (414 Da, Ligand)
- Water (18 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
cryo EM map of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7dsq
Q-score: 0.495
Yan R, Li Y, Muller J, Zhang Y, Singer S, Xia L, Zhong X, Gertsch J, Altmann KH, Zhou Q
Cell Discov (2021) 7 pp. 16-16 [ Pubmed: 33758168 DOI: doi:10.1038/s41421-021-00247-4 ]
- Water (18 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- Lat1-4f2hc bound with 3,5-diiodo-l-tyrosine (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 3,5-diiodotyrosine (432 Da, Ligand)