Cryo-EM structure of human Anion Exchanger 1 bound to Dipyridamole
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8t6u
Q-score: 0.469
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol (504 Da, Ligand)
- Band 3 anion transport protein (58 kDa, Protein from Homo sapiens)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8t6v
Q-score: 0.479
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (58 kDa, Protein from Homo sapiens)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
- 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid (454 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human Anion Exchanger 1
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7ty4
Q-score: 0.463
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7ty6
Q-score: 0.503
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
- 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid (454 Da, Ligand)
Cryo-EM structure of human Anion Exchanger 1 bound to Bicarbonate
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7ty7
Q-score: 0.419
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Bicarbonate ion (61 Da, Ligand)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
Cryo-EM structure of human Anion Exchanger 1 bound to Niflumic Acid
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7ty8
Q-score: 0.432
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ Pubmed: 37679563 DOI: doi:10.1038/s41594-023-01085-6 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid (282 Da, Ligand)
- Band 3 anion transport protein (101 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)
Cryo-EM structure of human Anion Exchanger 1 modified with Diethyl Pyrocarbonate (DEPC)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 7tya
Q-score: 0.506
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023) 30 pp. 1495-1504 [ DOI: doi:10.1038/s41594-023-01085-6 Pubmed: 37679563 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Water (18 Da, Ligand)
- Band 3 anion transport protein (102 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Dimeric anion exchanger 1 (slc4a1) (203 kDa, Complex from Homo sapiens)