FSHR-Follicle stimulating hormone-compound 716340-Gs complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8i2g
Q-score: 0.363
Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE
Nat Commun (2023) 14 pp. 519-519 [ DOI: doi:10.1038/s41467-023-36170-3 Pubmed: 36720854 ]
- Palmitic acid (256 Da, Ligand)
- Fshr-follicle stimulating hormone-compound 716340-gs complex (Complex from Homo sapiens)
- Follicle-stimulating hormone receptor (76 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- N-tert-butyl-n-ethyl-8-methoxy-9-propan-2-yloxy-1-thiophen-2-yl-5,6-dihydroimidazo[5,1-a]isoquinoline-3-carboxamide (467 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Follitropin subunit beta (12 kDa, Protein from Homo sapiens)
- Chimera of guanine nucleotide-binding protein g(s) subunit alpha and guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (30 kDa, Protein from Homo sapiens)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ DOI: doi:10.1038/s41421-022-00499-8 Pubmed: 36543774 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7xw5
Q-score: 0.482
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ DOI: doi:10.1038/s41586-022-05173-3 Pubmed: 35940204 ]
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Thyrotropin subunit beta (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
TSHR-Gs-M22 antibody-ML109 complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 7xw6
Q-score: 0.441
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ DOI: doi:10.1038/s41586-022-05173-3 Pubmed: 35940204 ]
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- M22 antibody light chain (11 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- The complex was assembled by co-expression. (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- M22 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)