Cryo-EM structure of human SIDT1 protein with C1 symmetry at neutral pH
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8woq
Q-score: 0.501
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Water (18 Da, Ligand)
- Ternary complex of sidt1 in complex with unknown lipids (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide (425 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Oleic acid (282 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at neutral pH
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8wor
Q-score: 0.533
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Water (18 Da, Ligand)
- Ternary complex of sidt1 in complex with unknown lipids (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide (425 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Oleic acid (282 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wos
Q-score: 0.418
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8wot
Q-score: 0.458
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of CXCR3 complexed with antagonist AMG487
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k2w
Q-score: 0.501
Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H
Cell Discov (2023) 9 pp. 119-119 [ Pubmed: 38012179 DOI: doi:10.1038/s41421-023-00617-0 ]
- Cxcr3-kor-amg487-nb6 (Complex from Homo sapiens)
- [1-myristoyl-glycerol-3-yl]phosphonylcholine (468 Da, Ligand)
- N-[(1r)-1-[3-(4-ethoxyphenyl)-4-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl]ethyl]-n-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyloxy)phenyl]ethanamide (603 Da, Ligand)
- Nb6 (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor (56 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
CXCR3-DNGi complex activated by CXCL10
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8k2x
Q-score: 0.516
Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H
Cell Discov (2023) 9 pp. 119-119 [ Pubmed: 38012179 DOI: doi:10.1038/s41421-023-00617-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Oplophorus gracilirostris)
- Cxcr3-cxcl10-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- C-x-c motif chemokine 10 (10 kDa, Protein from Homo sapiens)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ Pubmed: 36543774 DOI: doi:10.1038/s41421-022-00499-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
Structure of A2BR bound to synthetic agonists BAY 60-6583
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8hdo
Q-score: 0.497
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ DOI: doi:10.1038/s41421-022-00503-1 Pubmed: 36575181 ]
- A2br-g protein-bay 60-6583 complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Cholesterol (386 Da, Ligand)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
Structure of A2BR bound to endogenous agonists adenosine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hdp
Q-score: 0.428
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ DOI: doi:10.1038/s41421-022-00503-1 Pubmed: 36575181 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- A2br-g protein-adenosine complex (160 kDa, Complex from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Adenosine (267 Da, Ligand)
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of an alphavirus, Getah virus
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7fd2
Q-score: 0.452
Wang A, Zhou F, Liu C, Gao D, Qi R, Yin Y, Liu S, Gao Y, Fu L, Xia Y, Xu Y, Wang C, Liu Z
Cell Discov (2022) 8 pp. 12-12 [ DOI: doi:10.1038/s41421-022-00374-6 Pubmed: 35149682 ]
- Capsid protein (30 kDa, Protein from Getah virus)
- Envelope glycoprotein 2 (46 kDa, Protein from Getah virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Envelope glycoprotein 1 (47 kDa, Protein from Getah virus)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Stearic acid (284 Da, Ligand)
- Getah virus (Virus from Getah virus)