ABCB1 L335C mutant (mABCB1) in the inward facing state bound to AAC
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8pee
Q-score: 0.379
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4s,11s,18s)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (692 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
The ABCB1 L335C mutant (mABCB1) in the outward facing state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7zk4
Q-score: 0.569
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
ABCB1 L335C mutant (mABCB1) in the outward facing state bound to AAC
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7zk5
Q-score: 0.571
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
ABCB1 L335C mutant (mABCB1) in the outward facing state bound to 2 molecules of AAC
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7zk6
Q-score: 0.488
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- (4s,11s,18s)-4-[[(2,4-dinitrophenyl)disulfanyl]methyl]-11,18-dimethyl-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (692 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
ABCB1 L971C mutant (mABCB1) in the outward facing state bound to AAC
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7zk8
Q-score: 0.511
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Atp-dependent translocase abcb1 (140 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abcb1 (140 MDa, Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
ABCB1 V978C mutant (mABCB1) in the outward facing state bound to AAC
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7zka
Q-score: 0.533
Gewering T, Waghray D, Parey K, Jung H, Tran NNB, Zapata J, Zhao P, Chen H, Januliene D, Hummer G, Urbatsch I, Moeller A, Zhang Q
eLife (2024) 12 [ DOI: doi:10.7554/eLife.90174 Pubmed: 38259172 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-dependent translocase abcb1 (146 kDa, Protein from Mus musculus)
- Abcb1 (140 MDa, Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- (4~{s},11~{s},18~{s})-4,11-dimethyl-18-(sulfanylmethyl)-6,13,20-trithia-3,10,17,22,23,24-hexazatetracyclo[17.2.1.1^{5,8}.1^{12,15}]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (494 Da, Ligand)
Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7py4
Q-score: 0.523
Dieudonne T, Herrera SA, Laursen MJ, Lejeune M, Stock C, Slimani K, Jaxel C, Lyons JA, Montigny C, Pomorski TG, Nissen P, Lenoir G
eLife (2022) 11 [ Pubmed: 35416773 DOI: doi:10.7554/eLife.75272 ]
- Beryllium trifluoride ion (66 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cell cycle control protein 50a (37 kDa, Protein from Homo sapiens)
- Atp8b1-cdc50a (186 kDa, Complex from Homo sapiens)
- Phospholipid-transporting atpase ic (144 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of human TRPC5 in complex with clemizole
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7d4p
Q-score: 0.563
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ DOI: doi:10.7554/eLife.63429 Pubmed: 33683200 ]
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole (325 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of human TRPC5 in complex with HC-070
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7d4q
Q-score: 0.581
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ DOI: doi:10.7554/eLife.63429 Pubmed: 33683200 ]
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (475 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6v22
Q-score: 0.508
eLife (2019) 8 [ Pubmed: 31815672 DOI: doi:10.7554/eLife.51409 ]
- Potassium ion (39 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hsslo1 alpha subunit-beta4 subunit complex (580 kDa, Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Calcium-activated potassium channel subunit alpha-1 (119 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calcium-activated potassium channel subunit beta-4 (24 kDa, Protein from Homo sapiens)