Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7py4
Q-score: 0.523
Dieudonne T, Herrera SA, Laursen MJ, Lejeune M, Stock C, Slimani K, Jaxel C, Lyons JA, Montigny C, Pomorski TG, Nissen P, Lenoir G
eLife (2022) 11 [ Pubmed: 35416773 DOI: doi:10.7554/eLife.75272 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cell cycle control protein 50a (37 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Atp8b1-cdc50a (186 kDa, Complex from Homo sapiens)
- Beryllium trifluoride ion (66 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Phospholipid-transporting atpase ic (144 kDa, Protein from Homo sapiens)
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 7cfs
Q-score: 0.483
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
eLife (2020) 9 [ DOI: doi:10.7554/eLife.57096 Pubmed: 32915133 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hasic1a (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Acid-sensing ion channel 1 (54 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6uy0
Q-score: 0.515
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.56451 Pubmed: 32458799 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) (170 kDa, Complex from Bos taurus)
- Multidrug resistance-associated protein 1 (172 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 6uz8
Q-score: 0.573
Bai Y, Yu X, Chen H, Horne D, White R, Wu X, Lee P, Gu Y, Ghimire-Rijal S, Lin DC, Huang X
eLife (2020) 9 [ Pubmed: 32149605 DOI: doi:10.7554/eLife.53311 ]
- 2-[[(2~{s})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium (594 Da, Ligand)
- Short transient receptor potential channel 6 (97 kDa, Protein from Homo sapiens)
- (5-chloro-1'h-spiro[indole-3,4'-piperidin]-1'-yl)[(2r)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone (382 Da, Ligand)
- Trpc6 (Cellular component from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 6uza
Q-score: 0.568
Bai Y, Yu X, Chen H, Horne D, White R, Wu X, Lee P, Gu Y, Ghimire-Rijal S, Lin DC, Huang X
eLife (2020) 9 [ Pubmed: 32149605 DOI: doi:10.7554/eLife.53311 ]
- Trpc6 (Cellular component from Homo sapiens)
- 2-[[(2~{s})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium (396 Da, Ligand)
- 4-({(1r,2r)-2-[(3r)-3-aminopiperidin-1-yl]-2,3-dihydro-1h-inden-1-yl}oxy)benzonitrile (333 Da, Ligand)
- Short transient receptor potential channel 6 (97 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- [(2~{s})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl] octadecanoate (607 Da, Ligand)
Electron cryo-microscopy structure of the canonical TRPC4 ion channel
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6g1k
Q-score: 0.426
Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, Gatsogiannis C, Raunser S
eLife (2018) 7 [ DOI: doi:10.7554/eLife.36615 Pubmed: 29717981 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 (432 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)