Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7dty
Q-score: 0.436
Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW
eLife (2021) 10 [ DOI: doi:10.7554/eLife.68719 Pubmed: 34254582 ]
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with gip and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
Structure of human TRPC5 in complex with clemizole
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7d4p
Q-score: 0.563
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole (325 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human TRPC5 in complex with HC-070
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7d4q
Q-score: 0.581
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (475 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Human TRPC5 apo state structure at 3 angstrom
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7e4t
Q-score: 0.518
Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L
eLife (2021) 10 [ Pubmed: 33683200 DOI: doi:10.7554/eLife.63429 ]
- Zinc ion (65 Da, Ligand)
- Human transient receptor potential channel 5 tetramer (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)