Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8f0j
Q-score: 0.621
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ Pubmed: 37537379 DOI: doi:10.1038/s41589-023-01393-4 ]
- Palmitic acid (256 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Water (18 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pramlintide analogue san45 (3 kDa, Protein from Homo sapiens)
- Calcitonin receptor in complex with gs protein and san45 peptide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8f0k
Q-score: 0.564
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ Pubmed: 37537379 DOI: doi:10.1038/s41589-023-01393-4 ]
- Palmitic acid (256 Da, Ligand)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- San385 (3 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Human amylin 3 receptor in complex with gs protein and san385 peptide (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8f2b
Q-score: 0.556
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ Pubmed: 37537379 DOI: doi:10.1038/s41589-023-01393-4 ]
- Palmitic acid (256 Da, Ligand)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Water (18 Da, Ligand)
- Amylin 3 receptor in complex with gs protein and san45 peptide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pramlintide analogue san45 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7t2g
Q-score: 0.672
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G
Nat Chem Biol (2022) [ DOI: doi:10.1038/s41589-022-01208-y Pubmed: 36411392 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Soluble cytochrome b562,mu-type opioid receptor (55 kDa, Protein from Mus musculus)
- Mu-opioid receptor / gi protein complex bound to mitragynine pseudoindoxyl (mp). (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mitragynine pseudoindoxyl (414 Da, Ligand)
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7y27
Q-score: 0.464
Nat Chem Biol (2023) 19 pp. 133-140 [ DOI: doi:10.1038/s41589-022-01130-3 Pubmed: 36138141 ]
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Sst-14 (Complex)
- Complex of sstr2-minigq-scfv16 bound with sst-14 (Complex from Homo sapiens)
Cholesterol bound state of mTRPV2
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 7xem
Q-score: 0.44
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ Pubmed: 36163384 DOI: doi:10.1038/s41589-022-01139-8 ]
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Complex of mtrpv2 and cholesterol (Complex from Mus musculus)
- Water (18 Da, Ligand)
Resolution: 2.47 Å
EM Method: Single-particle
Fitted PDBs: 7xer
Q-score: 0.497
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ Pubmed: 36163384 DOI: doi:10.1038/s41589-022-01139-8 ]
- Cholesterol (386 Da, Ligand)
- Mtrpv2_q525t (Cellular component from Mus musculus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7xeu
Q-score: 0.5
Su N, Zhen W, Zhang H, Xu L, Jin Y, Chen X, Zhao C, Wang Q, Wang X, Li S, Wen H, Yang W, Guo J, Yang F
Nat Chem Biol (2023) 19 pp. 72-80 [ Pubmed: 36163384 DOI: doi:10.1038/s41589-022-01139-8 ]
- Cholesterol (386 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Mus musculus)
- Mtrpv2_e2 (Cellular component from Mus musculus)
Cryo-EM structure of the Apo CCR1-Gi complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vl8
Q-score: 0.454
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H
Nat Chem Biol (2022) 18 pp. 264-271 [ DOI: doi:10.1038/s41589-021-00918-z Pubmed: 34949837 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Apo form ccr1-gi complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)