Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xor
Q-score: 0.513
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ DOI: doi:10.1038/s41422-024-00997-2 Pubmed: 38997424 ]
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Gi1-gq chimeric (Complex from Mus musculus)
- Scfv16 (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Cholesterol (386 Da, Ligand)
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of ligand-bound form of the receptor in complex with the transducer (Complex from Rattus)
- Proteinase-activated receptor 1 (Complex)
Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xos
Q-score: 0.48
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ DOI: doi:10.1038/s41422-024-00997-2 Pubmed: 38997424 ]
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Tethered agonist-bound human par1-gi complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (40 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cyo-EM structure of wildtype non-gastric proton pump in the presence of Na+, AlF and ADP
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ijl
Q-score: 0.612
Biochim Biophys Acta Mol Cell Res (2023) 1870 pp. 119543-119543 [ DOI: doi:10.1016/j.bbamcr.2023.119543 Pubmed: 37482134 ]
- 2-{[(4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranoside (1 kDa, Ligand)
- Hetero dimer of alpha and beta subunit (135 MDa, Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (37 kDa, Protein from Rattus)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Sodium/potassium-transporting atpase subunit alpha (109 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Cyo-EM structure of K794A non-gastric proton pump in Na+ bound E1AMPPCP state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8ijm
Q-score: 0.412
Biochim Biophys Acta Mol Cell Res (2023) 1870 pp. 119543-119543 [ DOI: doi:10.1016/j.bbamcr.2023.119543 Pubmed: 37482134 ]
- Sodium/potassium-transporting atpase subunit alpha (109 kDa, Protein from Rattus)
- Hetero dimer of alpha and beta subunit (135 MDa, Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Sodium/potassium-transporting atpase subunit beta-1 (37 kDa, Protein from Rattus)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Galanin-bound galanin receptor 1 in complex with Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wq3
Q-score: 0.312
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y
Nat Commun (2022) 13 pp. 1364- [ DOI: doi:10.1038/s41467-022-29072-3 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Galanin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Galanin receptor type 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Galanin-gal1r-gi-scfv16 (Complex from Homo sapiens)
- Scfv16 (Complex)
- Galanin (Complex)
- Galanin receptor type 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus)
- Scfv16 (26 kDa, Protein from Mus musculus)
Galanin-bound galanin receptor 2 in complex with Gq
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7wq4
Q-score: 0.528
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y
Nat Commun (2022) 13 pp. 1364- [ DOI: doi:10.1038/s41467-022-29072-3 ]
- Galanin-gal2r-gq-nb35 (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (Complex from Rattus)
- Galanin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus)
- Galanin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Galanin receptor type 2 (Complex)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Nb35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Nb35 (Complex from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Lama glama)
- Galanin (Complex from Homo sapiens)