5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8fy8
Q-score: 0.519
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- 2-(5-methoxy-1h-indol-3-yl)-n,n-dimethylethan-1-amine (218 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8fye
Q-score: 0.53
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1h-indole (262 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8fyl
Q-score: 0.525
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8fyt
Q-score: 0.544
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8fyx
Q-score: 0.545
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024) 630 pp. 237-246 [ DOI: doi:10.1038/s41586-024-07403-2 Pubmed: 38720072 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Serotonin 1a (5-ht1a) receptor-gi1 protein complex (Complex from Escherichia coli, Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Buspirone (385 Da, Ligand)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a,5-hydroxytryptamine receptor 1a (61 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8jd5
Q-score: 0.427
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ DOI: doi:10.1038/s41422-023-00830-2 Pubmed: 37286794 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-methyl-n-(4-methylpyrimidin-2-yl)-4-(1h-pyrazol-4-yl)-1,3-thiazol-2-amine (272 Da, Ligand)
- Gi1-bound mglu2-mglu4 heterodimer (Complex from Homo sapiens)
- Metabotropic glutamate receptor 4 (102 kDa, Protein from Homo sapiens)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv (27 kDa, Protein from Escherichia coli)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 2 (95 kDa, Protein from Homo sapiens)
- 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one (344 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8djk
Q-score: 0.45
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
- Digitonin (1 kDa, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8djm
Q-score: 0.468
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X
Nat Commun (2022) 13 pp. 4273-4273 [ DOI: doi:10.1038/s41467-022-32025-5 Pubmed: 35879350 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase (41 kDa, Protein from Cricetulus griseus)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex from Cricetulus griseus)
- Fab 15b2 heavy chain (25 kDa, Protein from Mus musculus)
- Fab 15b2 light chain (23 kDa, Protein from Mus musculus)
- Ubia prenyltransferase domain-containing protein 1 (32 kDa, Protein from Cricetulus griseus)
- Soluble cytochrome b562 (13 kDa, Protein from Escherichia coli)
- Hmgcr-ubiad1-bril-fab 15b2 complex (Complex)
- Digitonin (1 kDa, Ligand)
The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7euo
Q-score: 0.525
Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD
Nat Commun (2022) 13 pp. 5232-5232 [ Pubmed: 36064945 DOI: doi:10.1038/s41467-022-32822-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Peptdie agonist fmlf (Complex)
- Peptide agonist fmlf (437 Da, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Fmet-leu-phe receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Complex of fpr1 with gi and peptdie agonist fmlf (Complex from Homo sapiens)
- Scfv16 (Complex)
- Fpr1 with gi (Complex from Mus musculus)