Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8h38
Q-score: 0.078
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Cop9 signalosome complex subunit 3 (47 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Csn (Complex)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (29 kDa, Protein from Homo sapiens)
- Nedd8 (Complex)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Kbtbd2-crl3~n8 dimer assemble with csn(mutate) monomer (Complex from Homo sapiens)
- Csn subunit1, kbtbd2, cullin-3, rbx1 (Complex)
Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex
Resolution: 7.51 Å
EM Method: Single-particle
Fitted PDBs: 8h3a
Q-score: -0.024
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (47 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (29 kDa, Protein from Homo sapiens)
- Kbtbd2, cullin-3, rbx1 (Complex)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Csn (Complex)
- Cryo-em structure of the kbtbd2-crl3~n8-csn complex (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CRL3-CSN complex
Resolution: 6.73 Å
EM Method: Single-particle
Fitted PDBs: 8h3f
Q-score: -0.046
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Cryo-em structure of the kbtbd2-crl3-csn complex (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 7b (24 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Csn (Complex)
- Kbtbd2-crl3 (Complex)
- Kelch repeat and btb domain-containing protein 2 (73 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.4 Å
EM Method: Single-particle
Fitted PDBs: 6r6h
Q-score: 0.146
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ DOI: doi:10.1038/s41467-019-11772-y Pubmed: 31444342 ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Eloc_human (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (17 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Rbx1_human (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cullin-ring e3 ligases (crls) complexes with neddylated cop9 signalosome (csn) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (34 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7f
Q-score: 0.001
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ DOI: doi:10.1038/s41467-019-11772-y Pubmed: 31444342 ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn) and neddylated cullin-ring e3 ligase crl (cullin-2 with rbx1, elongin-b, elongin-c and vhl) (Complex from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6r7h
Q-score: 0.05
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ DOI: doi:10.1038/s41467-019-11772-y Pubmed: 31444342 ]
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn1-csn8) with cullin-ring e3 ligase deneddylated cullin-2, rbx1, elongin-b and elonginc (Complex from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cullin-2 (76 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (48 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6r7i
Q-score: 0.148
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ DOI: doi:10.1038/s41467-019-11772-y Pubmed: 31444342 ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Elongin-c (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Csn-crl2-n8 (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (52 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6r7n
Q-score: 0.136
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ DOI: doi:10.1038/s41467-019-11772-y Pubmed: 31444342 ]
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Csn7b_human (23 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cns (cop9 signalosome) with csn5/csn6 the catalytic heterodimer complexed with cul2 (cul2, elonginb, elongingc, rbx1 and vdl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Rbx1 e3 ubiquitin-protein ligase (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)