Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.4 Å
EM Method: Single-particle
Fitted PDBs: 6r6h
Q-score: 0.146
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Eloc_human (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (34 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Rbx1_human (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (17 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cullin-ring e3 ligases (crls) complexes with neddylated cop9 signalosome (csn) (Complex from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7f
Q-score: 0.001
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn) and neddylated cullin-ring e3 ligase crl (cullin-2 with rbx1, elongin-b, elongin-c and vhl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6r7h
Q-score: 0.05
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (48 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn1-csn8) with cullin-ring e3 ligase deneddylated cullin-2, rbx1, elongin-b and elonginc (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cullin-2 (76 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6r7i
Q-score: 0.148
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Elongin-c (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Csn-crl2-n8 (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 1 (52 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6r7n
Q-score: 0.136
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cns (cop9 signalosome) with csn5/csn6 the catalytic heterodimer complexed with cul2 (cul2, elonginb, elongingc, rbx1 and vdl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Rbx1 e3 ubiquitin-protein ligase (10 kDa, Protein from Homo sapiens)
- Csn7b_human (23 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)