Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8soj
Q-score: 0.34
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T
Cell (2024) 187 pp. 3638-3651.e18 [ DOI: doi:10.1016/j.cell.2024.05.002 Pubmed: 38838667 ]
- Cst complex subunit ctc1 (178 kDa, Protein from Homo sapiens)
- Human cst-pot1(esdl)/tpp1 complex (380 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Protection of telomeres protein 1 (72 kDa, Protein from Homo sapiens)
- Cst complex subunit stn1 (115 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8sok
Q-score: 0.283
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T
Cell (2024) 187 pp. 3638-3651.e18 [ DOI: doi:10.1016/j.cell.2024.05.002 Pubmed: 38838667 ]
- Tpp1 (58 kDa, Protein from Homo sapiens)
- Dna (5'-d(*tp*tp*ap*gp*gp*gp*tp*tp*ap*g)-3') (5 kDa, DNA from synthetic construct)
- Ssdna-bound human cst-pot1(esdl)/tpp1 complex (370 kDa, Complex from Homo sapiens)
- Cst complex subunit ctc1 (178 kDa, Protein from Homo sapiens)
- Cst complex subunit stn1 (42 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Protection of telomeres protein 1 (72 kDa, Protein from Homo sapiens)
Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8d0b
Q-score: 0.417
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ
Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]
- Dna primase large subunit (28 kDa, Protein from Homo sapiens)
- Cst complex subunit ctc1 (133 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (130 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*ap*g)-3') (4 kDa, DNA from Homo sapiens)
- Cst complex subunit stn1 (41 kDa, Protein from Homo sapiens)
- Dna polymerase alpha subunit b (50 kDa, Protein from Homo sapiens)
- Human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback dna template (540 kDa, Complex from Homo sapiens)
- Dna primase small subunit (49 kDa, Protein from Homo sapiens)
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 8d0k
Q-score: 0.311
He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ
Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]
- Dna primase large subunit (60 kDa, Protein from Homo sapiens)
- Dna primase small subunit (51 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (17 kDa, Protein from Homo sapiens)
- Human cst-dna polymerase alpha/primase advanced preinitiation complex bound to 4xtel-foldback dna template (540 kDa, Complex from Homo sapiens)
- Cst complex subunit ctc1 (138 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*a)-3') (18 kDa, DNA from Homo sapiens)
- Cst complex subunit stn1 (43 kDa, Protein from Homo sapiens)
- Dna polymerase alpha subunit b (67 kDa, Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit (172 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u5c
Q-score: 0.33
Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
Nat Struct Mol Biol (2022) 29 pp. 813-819 [ Pubmed: 35578024 DOI: doi:10.1038/s41594-022-00766-y ]
- Dna polymerase alpha catalytic subunit (129 kDa, Protein from Homo sapiens)
- Dna primase large subunit (59 kDa, Protein from Homo sapiens)
- Cst complex subunit stn1 (42 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Human cst bound to dna polymerase alpha(pola1 delta n)-primase in a recruitment state (500 kDa, Complex)
- Dna primase small subunit (49 kDa, Protein from Homo sapiens)
- Canonical telomeric dna sequence (5 kDa, DNA from Homo sapiens)
- Dna polymerase alpha subunit b (66 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Cst complex subunit ctc1 (135 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Human CST bound to full-length DNA polymerase alpha-primase in a recruitment state
Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
Nat Struct Mol Biol (2022) 29 pp. 813-819 [ Pubmed: 35578024 DOI: doi:10.1038/s41594-022-00766-y ]
- Cst complex subunit ten1 (Protein from Homo sapiens)
- Telomeric g-strand ssdna (3 repeats) (DNA from Homo sapiens)
- Cst complex subunit ctc1 (Protein from Homo sapiens)
- Dna polymerase alpha catalytic subunit pola1 (Protein from Homo sapiens)
- Cst complex subunit stn1 (Protein from Homo sapiens)
- Dna primase large subunit prim2 (Protein from Homo sapiens)
- Dna primase catalytic subunit (Protein from Homo sapiens)
- Cst bound to full-length dna polymerase alpha-primase and ssdna (540 kDa, Complex)
- Dna polymerase alpha b subunit pola2 (Protein from Homo sapiens)
The structure of human CST reveals a decameric assembly bound to telomeric DNA
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- Homo sapiens cst complex subunit stn1 (Protein from Homo sapiens)
- Decameric assembly of human cst complex with telomeric single-stranded dna (2 MDa, Complex from Homo sapiens)
- Homo sapiens cst complex subunit ten1 (Protein from Homo sapiens)
- Homo sapiens cst complex subunit ctc1 (Protein from Homo sapiens)
- 3xtel (DNA from Homo sapiens)
Cryo-EM structure of CST bound to telomeric single-stranded DNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6w6w
Q-score: 0.536
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- Cst complex subunit ten1 (17 kDa, Protein from Homo sapiens)
- Human cst complex (200 kDa, Complex from Homo sapiens)
- Cst complex subunit ctc1 (136 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*tp*ap*gp*g)-3') (1 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit stn1 (43 kDa, Protein from Homo sapiens)