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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"CWC22" AND database:"EMDB" AND resolution:[5 TO 6}

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EMD-16658

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Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).

Release date: May 10, 2023
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 8ch6
Q-score: 0.154

Schmitzova J, Cretu C, Dienemann C, Urlaub H, Pena V

Nature (2023) 617 pp. 842-850 [ Pubmed: 37165190 DOI: doi:10.1038/s41586-023-06049-w ]

Sample:

Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
G-patch domain and kow motifs-containing protein (52 kDa, Protein from Homo sapiens)
Bud13 homolog (70 kDa, Protein from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
Rnu6-1 (34 kDa, RNA from Homo sapiens)
Rnu2-1 (60 kDa, RNA from Homo sapiens)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Late human activated spliceosome arrested with a dominant-negative mutant of the splicing helicase aquarius (aquarius k829a) (Complex from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 4 (57 kDa, Protein from Homo sapiens)
Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Homo sapiens)
Rnu5a-1 (37 kDa, RNA from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
Minx-m3 (102 kDa, RNA from unidentified adenovirus)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)

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EMD-6889

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cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.

Release date: Sept. 19, 2018
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 5z56
Q-score: 0.131

Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y

Cell Res (2018) 28 pp. 307-322 [ Pubmed: 29360106 DOI: doi:10.1038/cr.2018.14 ]

Sample:

Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
Bud13 homolog (70 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
Smad nuclear-interacting protein 1 (45 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Human activated spliceosome (Complex from Homo sapiens)
Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
U5 snrna (37 kDa, RNA from Homo sapiens)
Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
Skip (62 kDa, Protein from Homo sapiens)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
Putative pre-mrna-splicing factor atp-dependent rna helicase dhx16 (119 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
Pre-mrna (87 kDa, RNA from unidentified adenovirus)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Small nuclear ribonucleoprotein-associated proteins b and b' (23 kDa, Protein from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)

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EMD-3545

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Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)

Release date: March 22, 2017
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5mqf
Q-score: 0.202

Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Lu Hrmann R

Nature (2017) 542 pp. 318-323 [ Pubmed: 28076346 DOI: doi:10.1038/nature21079 ]

Sample:

Eukaryotic initiation factor 4a-iii (46 kDa, Protein from Human)
Human c* spliceosome, masked refinement (Complex from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Intron-binding protein aquarius (173 kDa, Protein from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Minx pre-mrna (intron) (104 kDa, RNA from Human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
Homo sapiens u5 a small nuclear rna (36 kDa, RNA from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
Homo sapiens rna, u6 small nuclear 1 (rnu6-1), small nuclear rna (34 kDa, RNA from Human)
Pre-mrna-processing factor 19 (55 kDa, Protein from Human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
Human gene for small nuclear rna u2 (snrna u2) (60 kDa, RNA from Human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from Human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Human)

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Sort by: Download

Showing 1 - 3 of 3. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [3]

Format:

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Shell (Unix-based) Batch (Windows-based)

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