Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 9chu
Q-score: 0.478
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ DOI: doi:10.1073/pnas.2414544121 Pubmed: 39565314 ]
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Noradrenaline (170 Da, Ligand)
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (49 kDa, Protein from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Fkbp1a (Complex from Homo sapiens)
cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in apo state
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 9chv
Q-score: 0.39
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ DOI: doi:10.1073/pnas.2414544121 Pubmed: 39565314 ]
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (51 kDa, Protein from Homo sapiens)
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Fkbp1a (Complex from Homo sapiens)
cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9chx
Q-score: 0.431
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ DOI: doi:10.1073/pnas.2414544121 Pubmed: 39565314 ]
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (51 kDa, Protein from Homo sapiens)
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Fkbp1a (Complex from Homo sapiens)
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
Structure of the PI4KA complex bound to Calcineurin
Shaw AL, Suresh S, Parson MAH, Harris NJ, Jenkins ML, Yip CK, Burke JE
Structure (2024) 32 pp. 1973- [ DOI: doi:10.1016/j.str.2024.08.007 Pubmed: 39216471 ]
- Hyccin (34 kDa, Protein from Homo sapiens)
- Tetratricopeptide repeat protein 7b (94 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4-kinase alpha (237 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Pi4ka complex bound to calcineurin (Complex from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (70 kDa, Protein from Homo sapiens)
- Calcineurin subunit b type 1 (19 kDa, Protein from Homo sapiens)