Carazolol-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ DOI: doi:10.1002/cplu.202400288 Pubmed: 39046191 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
- Carazolol bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
Epinephrine-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ DOI: doi:10.1002/cplu.202400288 Pubmed: 39046191 ]
- Epinephrine bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- L-epinephrine (183 Da, Ligand)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
ETB-eGt complex bound to endothelin-1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xgr
Q-score: 0.425
Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O
Biochem Biophys Res Commun (2024) 693 pp. 149361-149361 [ Pubmed: 38128244 DOI: doi:10.1016/j.bbrc.2023.149361 ]
- Endothelin receptor type b (67 kDa, Protein from Homo sapiens)
- Camelid antibody vhh fragment (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,egt-alpha (48 kDa, Protein from Bos taurus)
- Complex of endothelin-1, etb, egt trimer and nb35* (Complex from Homo sapiens)
Cryo-EM map of the full-length relaxin receptor RXFP1 in complex with heterotrimeric Gs
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ Pubmed: 37081311 DOI: doi:10.1038/s41589-023-01321-6 ]
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Camelid antibody vhh fragment nb35 (Protein from Lama glama)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tmw
Q-score: 0.336
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (113 kDa, Protein from Homo sapiens)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Camelid antibody vhh fragment nb35 (17 kDa, Protein from Lama glama)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Complex from Homo sapiens)
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7piv
Q-score: 0.539
Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P
Cell Res (2021) 31 pp. 1176-1189 [ DOI: doi:10.1038/s41422-021-00569-8 Pubmed: 34561620 ]
- Water (18 Da, Ligand)
- Melanocortin receptor 4 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ternary complex of the ndp-alpha-msh activated melanocortin 4 receptor (mc4r) gs protein complex stabilized by nanobody 35 (144 MDa, Complex from Homo sapiens)
- Ndp-alpha-msh (other names afamelanotide; scenesse) (1 kDa, Protein from synthetic construct)
- Camelid antibody vhh fragment - nanobody 35 (14 kDa, Protein from Lama glama)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7fig
Q-score: 0.377
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Luteinizing hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex (Complex)
- Camelid antibody vhh fragment nb35 (14 kDa, Protein from Lama glama)
- Gs protein (Complex from Bos taurus)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Antibody (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Chorionic gonadotropin (Complex from Homo sapiens)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
Structure of the Rhodopsin-Transducin-Nanobody Complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6oya
Q-score: 0.459
Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G
Mol Cell (2019) 75 pp. 781- [ DOI: doi:10.1016/j.molcel.2019.06.007 Pubmed: 31300275 ]
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Bos taurus)
- Rhodopsin (Complex from Bos taurus)
- Retinal (284 Da, Ligand)
- Nanobody (Complex from Lama glama)
- Transducin (Complex from Bos taurus)
- Rhodopsin-transducin-nanobody complex (141 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Gt-alpha/gi1-alpha chimera (41 kDa, Protein from Bos taurus)
- Camelid antibody vhh fragment (15 kDa, Protein from Lama glama)