Carazolol-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
- Carazolol bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
Epinephrine-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- L-epinephrine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Epinephrine bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
Cryo-EM map of the full-length relaxin receptor RXFP1 in complex with heterotrimeric Gs
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Protein from Homo sapiens)
- Camelid antibody vhh fragment nb35 (Protein from Lama glama)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Protein from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tmw
Q-score: 0.336
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Camelid antibody vhh fragment nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (113 kDa, Protein from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)