Carazolol-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
- Carazolol bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
Epinephrine-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- L-epinephrine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Epinephrine bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
ETB-eGt complex bound to endothelin-1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xgr
Q-score: 0.425
Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O
Biochem Biophys Res Commun (2024) 693 pp. 149361-149361 [ Pubmed: 38128244 DOI: doi:10.1016/j.bbrc.2023.149361 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- Complex of endothelin-1, etb, egt trimer and nb35* (Complex from Homo sapiens)
- Camelid antibody vhh fragment (17 kDa, Protein from Lama glama)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,egt-alpha (48 kDa, Protein from Bos taurus)
- Endothelin receptor type b (67 kDa, Protein from Homo sapiens)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7fig
Q-score: 0.377
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Chorionic gonadotropin (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Antibody (Complex from Lama glama)
- Gs protein (Complex from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Luteinizing hormone (Complex from Homo sapiens)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex (Complex)
- Camelid antibody vhh fragment nb35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)