Carazolol-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol (298 Da, Ligand)
- Carazolol bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
Epinephrine-activated human beta3 adrenergic receptor
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem (2024) 89 pp. e202400288-e202400288 [ Pubmed: 39046191 DOI: doi:10.1002/cplu.202400288 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- L-epinephrine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Camelid antibody vhh fragment (13 kDa, Protein from Lama glama)
- Single-chain fv16 (26 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (34 kDa, Protein from Homo sapiens)
- Epinephrine bounded human beta3 adrenergic receptor-gs protein complex with gbeta, ggamma, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Bos taurus)
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7piv
Q-score: 0.539
Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P
Cell Res (2021) 31 pp. 1176-1189 [ DOI: doi:10.1038/s41422-021-00569-8 Pubmed: 34561620 ]
- Ndp-alpha-msh (other names afamelanotide; scenesse) (1 kDa, Protein from synthetic construct)
- Calcium ion (40 Da, Ligand)
- Melanocortin receptor 4 (38 kDa, Protein from Homo sapiens)
- Ternary complex of the ndp-alpha-msh activated melanocortin 4 receptor (mc4r) gs protein complex stabilized by nanobody 35 (144 MDa, Complex from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Camelid antibody vhh fragment - nanobody 35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7fig
Q-score: 0.377
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE
Nature (2021) 598 pp. 688-692 [ DOI: doi:10.1038/s41586-021-03924-2 Pubmed: 34552239 ]
- Chorionic gonadotropin (Complex from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein hormones alpha chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Choriogonadotropin subunit beta 3 (17 kDa, Protein from Homo sapiens)
- Choriogonadotropin receptor (Complex from Homo sapiens)
- Antibody (Complex from Lama glama)
- Gs protein (Complex from Bos taurus)
- Lutropin-choriogonadotropic hormone receptor (78 kDa, Protein from Homo sapiens)
- Luteinizing hormone (Complex from Homo sapiens)
- Luteinizing hormone/choriogonadotropin receptor(s277i)-chorionic gonadotropin-gs complex (Complex)
- Camelid antibody vhh fragment nb35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
Structure of the Rhodopsin-Transducin-Nanobody Complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6oya
Q-score: 0.459
Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G
Mol Cell (2019) 75 pp. 781- [ Pubmed: 31300275 DOI: doi:10.1016/j.molcel.2019.06.007 ]
- Rhodopsin (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Nanobody (Complex from Lama glama)
- Rhodopsin-transducin-nanobody complex (141 kDa, Complex)
- Transducin (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Bos taurus)
- Retinal (284 Da, Ligand)
- Gt-alpha/gi1-alpha chimera (41 kDa, Protein from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Camelid antibody vhh fragment (15 kDa, Protein from Lama glama)