Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8b0f
Q-score: 0.482
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ Pubmed: 36797260 DOI: doi:10.1038/s41467-023-36441-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- C5b8-cd59 (Complex)
- Cd59 glycoprotein (13 kDa, Protein from Escherichia coli)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (Complex from Escherichia coli)
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
- Complement components c5, c6, c7 and c8 (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0g
Q-score: 0.399
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ Pubmed: 36797260 DOI: doi:10.1038/s41467-023-36441-z ]
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- Cd59 glycoprotein (9 kDa, Protein from Homo sapiens)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex from Homo sapiens)
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
2C9, C5b9-CD59 cryoEM structure
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8b0h
Q-score: 0.405
Couves EC, Gardner S, Voisin TB, Bickel JK, Stansfeld PJ, Tate EW, Bubeck D
Nat Commun (2023) 14 pp. 890-890 [ Pubmed: 36797260 DOI: doi:10.1038/s41467-023-36441-z ]
- Cd59 glycoprotein (Complex from Homo sapiens)
- 2c9, cd59 inhibited mac complex (Complex)
- Cd59 glycoprotein (14 kDa, Protein from Homo sapiens)
- Complement c5 (188 kDa, Protein from Homo sapiens)
- Complement component c6 (104 kDa, Protein from Homo sapiens)
- Complement components c5, c6, c7, c8 and c9 (Complex from Homo sapiens)
- Complement component c7 (93 kDa, Protein from Homo sapiens)
- Complement component c9 (63 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (67 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (65 kDa, Protein from Homo sapiens)
- Complement component c8 gamma chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7nyc
Q-score: 0.226
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ Pubmed: 34667172 DOI: doi:10.1038/s41467-021-26366-w ]
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- 3c9-smac (1 MDa, Complex from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7nyd
Q-score: 0.335
Menny A, Lukassen MV, Couves EC, Franc V, Heck AJR, Bubeck D
Nat Commun (2021) 12 pp. 6086-6086 [ Pubmed: 34667172 DOI: doi:10.1038/s41467-021-26366-w ]
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Complement c5 (186 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Alpha-l-fucopyranose (164 Da, Ligand)
- 2c9-smac (1 MDa, Complex from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h03
Q-score: 0.156
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- C7 (Complex from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- C6 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Closed conformation of the Membrane Attack Complex
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h04
Q-score: 0.179
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- C7 (Complex from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- C6 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Subtomogram average of the membrane attack complex
To Be Published
- Complement component c5b6 (285 kDa, Protein from Homo sapiens)
- Complement component c7 (92 kDa, Protein from Homo sapiens)
- Complement component c8-alpha chain (64 kDa, Protein from Homo sapiens)
- Complement component c9 chain (71 kDa, Protein from Homo sapiens)
- Complement component c8-beta chain (64 kDa, Protein from Homo sapiens)
- Complement component c8-gamma chain (22 kDa, Protein from Homo sapiens)
- Subtomogram average of the membrane attack complex pore in a lipid bilayer (Sample)