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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

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perform basic research in molecular biology

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offer vital services to scientists in the member states

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scientists, students and visitors at all levels

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More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Complex I-B14.5a" AND author_name:"La" AND resolution:[3 TO 4}

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EMD-11244

Download Map 3D View

Complex I during turnover, closed

Release date: Oct. 7, 2020
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6zkc
Q-score: 0.523

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Complex i during turnover, closed (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11248

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Complex I with NADH, closed

Release date: Oct. 7, 2020
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6zkg
Q-score: 0.48

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Complex i with nadh, closed (1 MDa, Complex from Ovis aries)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11249

Download Map 3D View

Complex I with NADH, open1

Release date: Oct. 7, 2020
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zkh
Q-score: 0.534

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Complex i with nadh, open1 (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11251

Download Map 3D View

Complex I with NADH, open3

Release date: Oct. 7, 2020
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zkj
Q-score: 0.533

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Complex i with nadh, open3 (1 MDa, Complex from Ovis aries)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione (322 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11252

Download Map 3D View

Complex I inhibited by rotenone, closed

Release date: Oct. 7, 2020
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6zkk
Q-score: 0.408

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
(2r,6as,12as)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6ah)-one (394 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Complex i inhibited by rotenone, closed (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11253

Download Map 3D View

Complex I inhibited by rotenone, open1

Release date: Oct. 7, 2020
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6zkl
Q-score: 0.488

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
(2r,6as,12as)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6ah)-one (394 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Complex i inhibited by rotenone, open1 (1 MDa, Complex from Ovis aries)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11256

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Native complex I, closed

Release date: Oct. 7, 2020
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6zko
Q-score: 0.412

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Native complex i, closed (1 MDa, Complex from Ovis aries)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11257

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Native complex I, open1

Release date: Oct. 7, 2020
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6zkp
Q-score: 0.533

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Native complex i, open1 (1 MDa, Complex from Ovis aries)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11258

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Native complex I, open2

Release date: Oct. 7, 2020
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6zkq
Q-score: 0.506

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Native complex i, open2 (1 MDa, Complex from Ovis aries)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

EMD-11259

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Native complex I, open3

Release date: Oct. 7, 2020
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6zkr
Q-score: 0.452

Kampjut D, Sazanov LA

Science (2020) 370 [ Pubmed: 32972993 DOI: doi:10.1126/science.abc4209 ]

Sample:

Flavin mononucleotide (456 Da, Ligand)
Potassium ion (39 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b4 (15 kDa, Protein from Sheep)
Fe2/s2 (inorganic) cluster (175 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sheep)
Mitochondrial complex i, mnll subunit (7 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a3 (9 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sheep)
Iron/sulfur cluster (351 Da, Ligand)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (748 Da, Ligand)
Mitochondrial complex i, kfyi subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b9 (21 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sheep)
Mitochondrial complex i, 49 kda subunit (52 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s3 (30 kDa, Protein from Sheep)
Mitochondrial complex i, pdsw subunit (20 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sheep)
Mitochondrial complex i, b14.7 subunit (14 kDa, Protein from Sheep)
Mitochondrial complex i, psst subunit (24 kDa, Protein from Sheep)
Mitochondrial complex i, mwfe subunit (8 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase core subunit s1 (79 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sheep)
Mitochondrial complex i, tyky subunit (24 kDa, Protein from Sheep)
Adenosine monophosphate (347 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sheep)
1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
Cardiolipin (1 kDa, Ligand)
Nadh:ubiquinone oxidoreductase subunit b7 (16 kDa, Protein from Sheep)
Mitochondrial complex i, b13 subunit (13 kDa, Protein from Sheep)
Zinc ion (65 Da, Ligand)
Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sheep)
Mitochondrial complex i, b17 subunit (15 kDa, Protein from Sheep)
Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Acyl carrier protein (17 kDa, Protein from Sheep)
Mitochondrial complex i, 13 kda subunit (13 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b3 (11 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sheep)
Mitochondrial complex i, b14.5a subunit (12 kDa, Protein from Sheep)
Mitochondrial complex i, 10 kda subunit (11 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a9 (43 kDa, Protein from Sheep)
Myristic acid (228 Da, Ligand)
Mitochondrial complex i, 24 kda subunit (27 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sheep)
Mitochondrial complex i, b16.6 subunit (16 kDa, Protein from Sheep)
Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sheep)
Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sheep)
Native complex i, open3 (1 MDa, Complex from Ovis aries)
Nadh:ubiquinone oxidoreductase subunit s5 (12 kDa, Protein from Sheep)
Mitochondrial complex i, esss subunit (17 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit a6 (16 kDa, Protein from Sheep)
S-[2-({n-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate (568 Da, Ligand)
Nadh:ubiquinone oxidoreductase subunit b2 (12 kDa, Protein from Sheep)
Nadh:ubiquinone oxidoreductase subunit b5 (21 kDa, Protein from Sheep)

[Show more]

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