Cryo-EM structure of a trapped ARIH1-diUB-CRL2-KLHDC10 complex - consensus map
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
Nat Commun (2024) 15 pp. 9899-9899 [ DOI: doi:10.1038/s41467-024-54126-z Pubmed: 39548056 ]
- Arih1 (Protein from Homo sapiens)
- Cul2 (Protein from Homo sapiens)
- Ub (Protein from Homo sapiens)
- Rbx1 (Protein from Homo sapiens)
- Elob (Protein from Homo sapiens)
- Klhdc10 (Protein from Homo sapiens)
- Nedd8 (Protein from Homo sapiens)
- Trapped arih1-diub-crl2-klhdc10 complex (270 kDa, Complex)
- Eloc (Protein from Homo sapiens)
Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9d8p
Q-score: 0.522
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
Nat Commun (2024) 15 pp. 9899-9899 [ DOI: doi:10.1038/s41467-024-54126-z Pubmed: 39548056 ]
- Kelch domain-containing protein 10 (45 kDa, Protein from Homo sapiens)
- Ubiquitin-c (8 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Trapped arih1-diub-crl2-klhdc10 complex (Complex)
Structure of Pol II-TC-NER-STK19 complex, focused on CRL4CSA
Ramadhin AR, Lee SH, Zhou D, Salmazo A, Gonzalo-Hansen C, van Sluis M, Blom CMA, Janssens RC, Raams A, Dekkers D, Bezstarosti K, Slade D, Vermeulen W, Pines A, Demmers JAA, Bernecky C, Sixma TK, Marteijn JA
Mol Cell (2024) 84 pp. 4740-4757.e12 [ Pubmed: 39547223 DOI: doi:10.1016/j.molcel.2024.10.030 ]
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Cullin-4a (Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (Protein from Homo sapiens)
- Nedd8 (Protein from Homo sapiens)
- Ternary complex of pol ii-tc-ner-stk19, focused on crl4csa (300 kDa, Complex from Homo sapiens)
- Dna excision repair protein ercc-8 (Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (Protein from Homo sapiens)
Crowe C, Nakasone MA, Chandler S, Craigon C, Sathe G, Tatham MH, Makukhin N, Hay RT, Ciulli A
Sci Adv (2024) 10 pp. eado6492-eado6492 [ DOI: doi:10.1126/sciadv.ado6492 Pubmed: 39392888 ]
Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL
Crowe C, Nakasone MA, Chandler S, Craigon C, Sathe G, Tatham MH, Makukhin N, Hay RT, Ciulli A
Sci Adv (2024) 10 pp. eado6492-eado6492 [ DOI: doi:10.1126/sciadv.ado6492 Pubmed: 39392888 ]
Structure of CRL2APPBP2 bound with RxxGP degron (dimer)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jal
Q-score: 0.473
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Leu-thr-arg-asn-lys-gly-pro (1 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGP degron (tetramer)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8jaq
Q-score: 0.443
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Xp_211896 c-degron (1 kDa, Protein from Homo sapiens)
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGPAA degron (dimer)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jar
Q-score: 0.468
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Zinc ion (65 Da, Ligand)
- Xp_211896+aa c-degron (1 kDa, Protein from Homo sapiens)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8jas
Q-score: 0.366
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Sumo-xp_211896+aa c-degron (1 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (dimer)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jau
Q-score: 0.478
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Mrpl28 c-degron (1 kDa, Protein from Homo sapiens)