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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Crooked neck-like protein 1" AND xref_links:"interpro" AND author_name:"Kastner"

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EMD-11697

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Human pre-Bact-2 spliceosome

Release date: Feb. 10, 2021
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 7abi
Q-score: 0.145

Townsend C, Leelaram MN, Agafonov DE, Dybkov O, Will CL, Bertram K, Urlaub H, Kastner B, Stark H, Luhrmann R

Science (2020) 370 [ DOI: doi:10.1126/science.abc3753 Pubmed: 33243851 ]

Sample:

Ubiquitin-like protein 5 (8 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
Zinc finger matrin-type protein 2 (23 kDa, Protein from Human)
Ring-type e3 ubiquitin-protein ligase ppil2 (58 kDa, Protein from Human)
Splicing factor 3b subunit 5 (10 kDa, Protein from Human)
Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Human)
Smad nuclear-interacting protein 1 (45 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Human)
U6 snrna (34 kDa, RNA from Human)
Splicing factor 3b subunit 6 (14 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
U2 snrna (60 kDa, RNA from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
Splicing factor 3a subunit 2 (49 kDa, Protein from Human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
Human pre-bact-2 spliceosome (Complex)
Beta-catenin-like protein 1 (65 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Pre-mrna-splicing factor 38a (37 kDa, Protein from Human)
Intron-binding protein aquarius (171 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Splicing factor 3a subunit 3 (58 kDa, Protein from Human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
Human pre-bact-2 spliceosome (Complex from Homo sapiens)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Splicing factor 3b subunit 2 (100 kDa, Protein from Human)
Splicing factor 3b subunit 4 (44 kDa, Protein from Human)
Dna/rna-binding protein kin17 (45 kDa, Protein from Human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
Splicing factor 3b subunit 1 (146 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
Splicing factor 3b subunit 3 (135 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
Minx m3 pre-mrna (Complex from synthetic construct)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
Splicing factor 3a subunit 1 (88 kDa, Protein from Human)
Bud13 homolog (70 kDa, Protein from Human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
Microfibrillar-associated protein 1 (52 kDa, Protein from Human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from Human)
U5 snrna (36 kDa, RNA from Human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Minx m3 pre-mrna (103 kDa, RNA from synthetic construct)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Human)

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EMD-11569

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Human C Complex Spliceosome - High-resolution CORE

Release date: Oct. 14, 2020
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6zym
Q-score: 0.498

Bertram K, El Ayoubi L, Dybkov O, Agafonov DE, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Luhrmann R

Mol Cell (2020) 80 pp. 127-139.e6 [ DOI: doi:10.1016/j.molcel.2020.09.012 Pubmed: 33007253 ]

Sample:

Corepressor interacting with rbpj 1 (52 kDa, Protein from Human)
Snw domain-containing protein 1 (61 kDa, Protein from Human)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from Human)
Human c complex spliceosome - high resolution core (Complex from Homo sapiens)
U2 snrna (60 kDa, RNA from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Wd repeat-containing protein 70 (73 kDa, Protein from Human)
Pre-mrna-splicing factor atp-dependent rna helicase prp16 (140 kDa, Protein from Human)
Pre-mrna-splicing factor cwc25 homolog (49 kDa, Protein from Human)
Splicing factor yju2 (21 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
Magnesium ion (24 Da, Ligand)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (107 kDa, Protein from Human)
U6 snrna (25 kDa, RNA from Human)
Pre-mrna-processing-splicing factor 8 (207 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Zinc ion (65 Da, Ligand)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
U5 snrna (36 kDa, RNA from Human)
Pre-mrna-splicing factor rbm22 (25 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)
Protein frg1 (29 kDa, Protein from Human)
Pre-mrna (103 kDa, RNA from Human)

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EMD-4255

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human Bact spliceosome core structure

Release date: Aug. 29, 2018
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6ff4
Q-score: 0.443

Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H

Cell (2018) 172 pp. 454-464.e11 [ Pubmed: 29361316 DOI: doi:10.1016/j.cell.2018.01.010 ]

Sample:

Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
U2 snrna (60 kDa, RNA from Homo sapiens)
Pre-mrna-processing factor 17 (65 kDa, Protein from Homo sapiens)
Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
Human bact spliceosome state 1 unmasked (4 MDa, Complex from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Serine/arginine repetitive matrix protein 1 (102 kDa, Protein from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
Snw domain-containing protein 1 (61 kDa, Protein from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
U5 snrna (36 kDa, RNA from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Homo sapiens)
Ring finger protein 113a (38 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
Rna-binding motif protein, x-linked 2 (37 kDa, Protein from Homo sapiens)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Zinc ion (65 Da, Ligand)
Pleiotropic regulator 1 (57 kDa, Protein from Homo sapiens)
Pre mrna (153 kDa, RNA from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase cwc27 homolog (53 kDa, Protein from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Splicing factor 3b subunit 6 (14 kDa, Protein from Homo sapiens)
Bud13 homolog (70 kDa, Protein from Homo sapiens)
Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)

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EMD-3545

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Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)

Release date: March 22, 2017
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5mqf
Q-score: 0.202

Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, Lu Hrmann R

Nature (2017) 542 pp. 318-323 [ Pubmed: 28076346 DOI: doi:10.1038/nature21079 ]

Sample:

Snw domain-containing protein 1 (61 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Human)
Pleiotropic regulator 1 (57 kDa, Protein from Human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from Human)
Human gene for small nuclear rna u2 (snrna u2) (60 kDa, RNA from Human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from Human)
Protein bud31 homolog (17 kDa, Protein from Human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Human)
Human c* spliceosome, masked refinement (Complex from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Human)
Crooked neck-like protein 1 (100 kDa, Protein from Human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Human)
Pre-mrna-processing factor 17 (65 kDa, Protein from Human)
Homo sapiens rna, u6 small nuclear 1 (rnu6-1), small nuclear rna (34 kDa, RNA from Human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from Human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from Human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from Human)
Minx pre-mrna (intron) (104 kDa, RNA from Human)
Pre-mrna-processing factor 19 (55 kDa, Protein from Human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Human)
Intron-binding protein aquarius (173 kDa, Protein from Human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from Human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Human)
Homo sapiens u5 a small nuclear rna (36 kDa, RNA from Human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from Human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from Human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from Human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from Human)

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Sort by: Download

Showing 1 - 4 of 4. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [4]

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Shell (Unix-based) Batch (Windows-based)

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