Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8fvi
Q-score: 0.431
Ito F, Alvarez-Cabrera AL, Kim K, Zhou ZH, Chen XS
Nat Commun (2023) 14 pp. 5241-5241 [ DOI: doi:10.1038/s41467-023-40955-x Pubmed: 37640699 ]
- Dna dc->du-editing enzyme apobec-3h (22 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Rna(5'-r(*ap*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, RNA from Escherichia coli)
- Core-binding factor subunit beta (18 kDa, Protein from Homo sapiens)
- Hetero-hexameric complex of hiv-1 vif and human apobec3h, cbf-beta, elob, eloc, and cul5 (120 kDa, Complex from Homo sapiens)
- Virion infectivity factor (21 kDa, Protein from Human immunodeficiency virus 1)
- Rna(5'-r(ap*up*up*up*up*up*up*up*up*u)-3') (3 kDa, RNA from Escherichia coli)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cullin 5 (36 kDa, Protein from Homo sapiens)
Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8fvj
Q-score: 0.374
Ito F, Alvarez-Cabrera AL, Kim K, Zhou ZH, Chen XS
Nat Commun (2023) 14 pp. 5241-5241 [ DOI: doi:10.1038/s41467-023-40955-x Pubmed: 37640699 ]
- Dimeric form of hiv-1 vif in complex with human cbf-beta, elob, eloc, and cul5 (198 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Core-binding factor subunit beta (18 kDa, Protein from Homo sapiens)
- Cullin-5 (36 kDa, Protein from Homo sapiens)
- Virion infectivity factor (21 kDa, Protein from Human immunodeficiency virus 1)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
HIV-1 Vif in complex with human APOBEC3H, CBF-beta, ELOB, ELOC, CUL5, and RBX2
Ito F, Alvarez-Cabrera AL, Kim K, Zhou ZH, Chen XS
Nat Commun (2023) 14 pp. 5241-5241 [ DOI: doi:10.1038/s41467-023-40955-x Pubmed: 37640699 ]
- Core-binding factor subunit beta (Protein from Homo sapiens)
- Ring-box protein 2 (Protein from Homo sapiens)
- Dna dc->du-editing enzyme apobec-3h (Protein from Homo sapiens)
- Virion infectivity factor (Protein from Human immunodeficiency virus 1)
- Elongin-b (Protein from Homo sapiens)
- Hetero-heptameric complex of hiv-1 vif and human apobec3h, cbf-beta, elob, eloc, cul5, and rbx2 (Complex from Homo sapiens)
- Elongin-c (Protein from Homo sapiens)
- Cullin-5 (Protein from Homo sapiens)
APOBEC3G in complex with HIV-1 Vif/CBF-beta/EloB/EloC/Cul5/Rbx2
Ito F, Alvarez-Cabrera AL, Liu S, Yang H, Shiriaeva A, Zhou ZH, Chen XS
Sci Adv (2023) 9 pp. eade3168-eade3168 [ DOI: doi:10.1126/sciadv.ade3168 Pubmed: 36598981 ]
- Core-binding factor subunit beta (Protein from Homo sapiens)
- Apobec3g (Protein from Macaca mulatta)
- Complex of apobec3g with hiv-1 vif, cbf-beta, elongin-b, elongin-c, cullin-5, and ring-box protein 2 (210 kDa, Complex from Human immunodeficiency virus 1)
- Ring-box protein 2 (Protein from Homo sapiens)
- Virion infectivity factor (Protein from Human immunodeficiency virus 1)
- Elongin-b (Protein from Homo sapiens)
- Elongin-c (Protein from Homo sapiens)
- Cullin-5 (Protein from Homo sapiens)
Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2*
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7oni
Q-score: 0.464
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Zinc ion (65 Da, Ligand)
- Cullin-5 (91 kDa, Protein from Homo sapiens)
- Ring-box protein 2 (12 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase arih2 (57 kDa, Protein from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex from Homo sapiens)
- Nedd8 (9 kDa, Protein from Homo sapiens)
Structure of Neddylated CRL5Vif-CBFbeta-ARIH2*-APOBEC3C (A3C fullcomplex consensus )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2* ( A3G E3-E3 catalytic focused )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
Structure of Neddylated CRL5Vif-CBFbeta-ARIH2*-APOBEC3C (A3C consensus )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
Structure of Neddylated CRL5Vif-CBFbeta-ARIH2*-APOBEC3G ( A3G consensus )
Kostrhon S, Prabu JR, Baek K, Horn-Ghetko D, von Gronau S, Klugel M, Basquin J, Alpi AF, Schulman BA
Nat Chem Biol (2021) 17 pp. 1075-1083 [ Pubmed: 34518685 DOI: doi:10.1038/s41589-021-00858-8 ]
- Arih2 (Complex from Homo sapiens)
- Neddylated cul5 c-terminal region-rbx2-arih2 (Complex)
- Rbx2 (Complex from Homo sapiens)
- Cullin-5 (Complex from Homo sapiens)
- Nedd8 (Complex from Homo sapiens)
cryo-EM structure of Cullin5 bound to RING-box protein 2 (Cul5-Rbx2)
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 6v9i
Q-score: 0.216
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA
Nat Commun (2020) 11 pp. 2866-2866 [ DOI: doi:10.1038/s41467-020-16499-9 Pubmed: 32513959 ]
- Immunoglobulin g-binding protein g,cullin-5 (100 kDa, Protein from Homo sapiens)
- Ring-box protein 2 (12 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Cryo-em structure of cullin5 bound to ring-box protein 2 (cul5-rbx2) (100 kDa, Complex from Homo sapiens)