Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ucj
Q-score: 0.507
To Be Published
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Cytochrome c oxidase subunit 4 (16 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Komagataella pastoris cytochrome c oxidase (11 subunits) in complex with human vmat2 (246 kDa, Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Cytochrome c oxidase subunit 13 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 12 (8 kDa, Protein from Komagataella pastoris)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8uck
Q-score: 0.486
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Komagataella pastoris cytochrome c oxidase (9 subunits) in complex with human vmat2 (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Tetrabenazine
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8ucl
Q-score: 0.511
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase-vmat2-tetrabenazine particle (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- (3s,5r,11bs)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-one (317 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Reserpine
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ucm
Q-score: 0.513
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Reserpine (608 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase-vmat2-reserpine particle (225 kDa, Complex from Homo sapiens)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Histamine
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8ucn
Q-score: 0.486
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Komagataella pastoris cytochrome c oxidase in complex with human vmat2 and histamine (225 kDa, Complex from Homo sapiens)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Histamine (111 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8uco
Q-score: 0.484
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Komagataella pastoris cytochrome c oxidase in complex with human vmat2 and amphetamin (225 kDa, Complex from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Zinc ion (65 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Serotonin
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ucp
Q-score: 0.491
To Be Published
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Cytochrome c oxidase subunit 5 (14 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 7 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase-vmat2-serotonin complex (225 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 8 (5 kDa, Protein from Komagataella pastoris)
- Copper (ii) ion (63 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 6 (11 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 9 (6 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Komagataella pastoris)
- Heme-a (852 Da, Ligand)
- Serotonin (176 Da, Ligand)
- Cytochrome c oxidase subunit 4 (12 kDa, Protein from Komagataella pastoris)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Komagataella pastoris)
- Phosphatidylethanolamine (734 Da, Ligand)
III2IV respiratory supercomplex from Saccharomyces cerevisiae
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9etz
Q-score: 0.639
Lobez AP, Wu F, Di Trani JM, Rubinstein JL, Oliveberg M, Brzezinski P, Moe A
Nat Commun (2024) 15 pp. 8241-8241 [ DOI: doi:10.1038/s41467-024-52475-3 Pubmed: 39300056 ]
- Cytochrome c1, heme protein, mitochondrial (27 kDa, Protein from Saccharomyces cerevisiae)
- Heme c (618 Da, Ligand)
- Cytochrome b-c1 complex subunit 1, mitochondrial (47 kDa, Protein from Saccharomyces cerevisiae)
- Heme-a (852 Da, Ligand)
- Cytochrome b-c1 complex subunit 8, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cytochrome c oxidase subunit 9, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit rieske, mitochondrial (20 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 26, mitochondrial (5 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 7, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 2, mitochondrial (38 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Saccharomyces cerevisiae)
- Copper (ii) ion (63 Da, Ligand)
- Cytochrome c oxidase subunit 5a, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 9, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Cytochrome b-c1 complex subunit 10, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Saccharomyces cerevisiae)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Cytochrome b-c1 complex subunit 6, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 12, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 7, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 4, mitochondrial (12 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 13, mitochondrial (13 kDa, Protein from Saccharomyces cerevisiae)
- 5-(3,7,11,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3-dimethoxy-6-methyl-benzene-1,4-diol (592 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cytochrome b (43 kDa, Protein from Saccharomyces cerevisiae)
- Cardiolipin (1 kDa, Ligand)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 8, mitochondrial (5 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 6, mitochondrial (12 kDa, Protein from Saccharomyces cerevisiae)
- Iii2-iv respiratory supercomplex (Complex from Saccharomyces cerevisiae)
In-situ structure of typeA supercomplex with lipids in respiratory chain (composite)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8ugh
Q-score: 0.464
Zheng W, Chai P, Zhu J, Zhang K
Nature (2024) 631 pp. 232-239 [ DOI: doi:10.1038/s41586-024-07488-9 Pubmed: 38811722 ]
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 2, mitochondrial (48 kDa, Protein from Sus scrofa)
- Cytochrome b (42 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 7c, mitochondrial (7 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 3 (29 kDa, Protein from Sus scrofa)
- Potassium ion (39 Da, Ligand)
- Cytochrome c oxidase subunit 6a2 (10 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit rieske, mitochondrial (29 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 1 (57 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit ab1 (17 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 6b1 (10 kDa, Protein from Sus scrofa)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform x1 (13 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 5a, mitochondrial (16 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Sus scrofa)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sus scrofa)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 5b, mitochondrial (13 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 7 (13 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit a13 (16 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sus scrofa)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Sus scrofa)
- Copper (ii) ion (63 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sus scrofa)
- N-acetylalanine (131 Da, Ligand)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Sus scrofa)
- N-acetylmethionine (191 Da, Ligand)
- (7r,17e,20e)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide (759 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Sus scrofa)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Cytochrome b-c1 complex subunit 8 (9 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit ndufa4 (9 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sus scrofa)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- (1r)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11e)-octadec-11-enoate (749 Da, Ligand)
- Heme c (618 Da, Ligand)
- In-situ cryo-em structure of respiratory supercomplex by directly imaging mitochondria (Complex from Sus scrofa)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (14 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit b2 (11 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from Sus scrofa)
- Ubiquinol-cytochrome c reductase complex 7.2 kda protein (7 kDa, Protein from Sus scrofa)
- Sodium ion (22 Da, Ligand)
- Cytochrome c oxidase subunit 7b (9 kDa, Protein from Sus scrofa)
- Phosphate ion (94 Da, Ligand)
- Cytochrome b-c1 complex subunit 6, mitochondrial (10 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit a9 (42 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 4 (19 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (28 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (27 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 10 (6 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 6c (8 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 7a1, mitochondrial (9 kDa, Protein from Sus scrofa)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5e,8e,11e,14e)-icosa-5,8,11,14-tetraenoate (768 Da, Ligand)
- Heme-a (852 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sus scrofa)
- Cytochrome c1 (35 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [sus scrofa] (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Sus scrofa)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (48 kDa, Protein from Sus scrofa)
- Iron/sulfur cluster (351 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 1, mitochondrial (52 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Cytochrome c oxidase subunit 8 (7 kDa, Protein from Sus scrofa)
- Dinuclear copper ion (127 Da, Ligand)
High resolution in-situ structure of typeA supercomplex in respiratory chain (I1III2IV1,composite)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8ugi
Q-score: 0.629
Zheng W, Chai P, Zhu J, Zhang K
Nature (2024) 631 pp. 232-239 [ DOI: doi:10.1038/s41586-024-07488-9 Pubmed: 38811722 ]
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 2, mitochondrial (48 kDa, Protein from Sus scrofa)
- Cytochrome b (42 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 7c, mitochondrial (7 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 3 (29 kDa, Protein from Sus scrofa)
- Potassium ion (39 Da, Ligand)
- Cytochrome c oxidase subunit 6a2 (10 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 2 (26 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit rieske, mitochondrial (29 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit ab1 (17 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 6b1 (10 kDa, Protein from Sus scrofa)
- Flavin mononucleotide (456 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform x1 (13 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (20 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 5a, mitochondrial (16 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from Sus scrofa)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from Sus scrofa)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 5b, mitochondrial (13 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 7 (13 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (54 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit a13 (16 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from Sus scrofa)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from Sus scrofa)
- Copper (ii) ion (63 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from Sus scrofa)
- N-acetylmethionine (191 Da, Ligand)
- (7r,17e,20e)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide (759 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from Sus scrofa)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Cytochrome b-c1 complex subunit 8 (9 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit ndufa4 (9 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from Sus scrofa)
- Cytochrome c1, heme protein, mitochondrial (35 kDa, Protein from Sus scrofa)
- (1r)-2-{[{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11e)-octadec-11-enoate (749 Da, Ligand)
- Heme c (618 Da, Ligand)
- In-situ cryo-em structure of respiratory supercomplex by directly imaging mitochondria (Complex from Sus scrofa)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (14 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit b2 (11 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 4 (51 kDa, Protein from Sus scrofa)
- Ubiquinol-cytochrome c reductase complex 7.2 kda protein (7 kDa, Protein from Sus scrofa)
- Sodium ion (22 Da, Ligand)
- Cytochrome c oxidase subunit 7b (9 kDa, Protein from Sus scrofa)
- Phosphate ion (94 Da, Ligand)
- Cytochrome b-c1 complex subunit 6, mitochondrial (10 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from Sus scrofa)
- Nadh:ubiquinone oxidoreductase subunit a9 (42 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 4 (19 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (28 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (27 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 10 (6 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 6c (8 kDa, Protein from Sus scrofa)
- Cytochrome c oxidase subunit 7a1, mitochondrial (9 kDa, Protein from Sus scrofa)
- Heme-a (852 Da, Ligand)
- (1s)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(stearoyloxy)methyl]ethyl (5e,8e,11e,14e)-icosa-5,8,11,14-tetraenoate (768 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (40 kDa, Protein from Sus scrofa)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from Sus scrofa)
- Water (18 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [sus scrofa] (15 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from Sus scrofa)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cytochrome c oxidase subunit 1 (56 kDa, Protein from Sus scrofa)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (48 kDa, Protein from Sus scrofa)
- Iron/sulfur cluster (351 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from Sus scrofa)
- Cytochrome b-c1 complex subunit 1, mitochondrial (52 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Cytochrome c oxidase subunit 8 (7 kDa, Protein from Sus scrofa)
- Dinuclear copper ion (127 Da, Ligand)