Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8rox
Q-score: 0.452
Lucas SCC, Ahmed A, Ashraf SN, Argyrou A, Bauer MR, De Donatis GM, Demanze S, Eisele F, Fusani L, Hock A, Kadamur G, Li S, Macmillan-Jones A, Michaelides IN, Phillips C, Rehnstrom M, Richter M, Rodrigo-Brenni MC, Shilliday F, Wang P, Storer RI
J Med Chem (2024) 67 pp. 5538-5566 [ DOI: doi:10.1021/acs.jmedchem.3c02136 Pubmed: 38513086 ]
- Complex of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to compound furan 24 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- 5-[[3,4-bis(chloranyl)-1~{h}-indol-7-yl]sulfamoyl]-~{n},~{n},3-trimethyl-furan-2-carboxamide;ethane (416 Da, Ligand)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8roy
Q-score: 0.477
Lucas SCC, Ahmed A, Ashraf SN, Argyrou A, Bauer MR, De Donatis GM, Demanze S, Eisele F, Fusani L, Hock A, Kadamur G, Li S, Macmillan-Jones A, Michaelides IN, Phillips C, Rehnstrom M, Richter M, Rodrigo-Brenni MC, Shilliday F, Wang P, Storer RI
J Med Chem (2024) 67 pp. 5538-5566 [ DOI: doi:10.1021/acs.jmedchem.3c02136 Pubmed: 38513086 ]
- Complex of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to compound furan 24 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
- 1-[5-[[3,4-bis(chloranyl)-1~{h}-indol-7-yl]sulfamoyl]-3-methyl-furan-2-yl]carbonyl-~{n}-methyl-piperidine-4-carboxamide (513 Da, Ligand)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ Pubmed: 31819272 DOI: doi:10.1038/s41589-019-0411-6 ]
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)
- Ddb1 complex (210 kDa, Complex)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Rbm39 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of DDB1dB-DCAF15-DDA1 bound to E7820 and RBM39
Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES
Nat Chem Biol (2020) 16 pp. 7-14 [ DOI: doi:10.1038/s41589-019-0378-3 Pubmed: 31686031 ]
- Det1 and ddb1 associated 1 (Protein from Homo sapiens)
- Complex of ddb1-dcaf15-dda1 bound to e7820 and the second rrm of rbm39 (193 kDa, Complex from Homo sapiens)
- Ddb1 and cul4 associated factor 15 (Protein from Homo sapiens)
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Rna binding motif protein 39 (Protein from Homo sapiens)
Cryo-EM structure of DDB1-DCAF15 bound to E7820 and the second RRM of RBM39
Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES
Nat Chem Biol (2020) 16 pp. 7-14 [ DOI: doi:10.1038/s41589-019-0378-3 Pubmed: 31686031 ]