Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8rox
Q-score: 0.452
Lucas SCC, Ahmed A, Ashraf SN, Argyrou A, Bauer MR, De Donatis GM, Demanze S, Eisele F, Fusani L, Hock A, Kadamur G, Li S, Macmillan-Jones A, Michaelides IN, Phillips C, Rehnstrom M, Richter M, Rodrigo-Brenni MC, Shilliday F, Wang P, Storer RI
J Med Chem (2024) 67 pp. 5538-5566 [ DOI: doi:10.1021/acs.jmedchem.3c02136 Pubmed: 38513086 ]
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Complex of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to compound furan 24 (Complex from Homo sapiens)
- 5-[[3,4-bis(chloranyl)-1~{h}-indol-7-yl]sulfamoyl]-~{n},~{n},3-trimethyl-furan-2-carboxamide;ethane (416 Da, Ligand)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8roy
Q-score: 0.477
Lucas SCC, Ahmed A, Ashraf SN, Argyrou A, Bauer MR, De Donatis GM, Demanze S, Eisele F, Fusani L, Hock A, Kadamur G, Li S, Macmillan-Jones A, Michaelides IN, Phillips C, Rehnstrom M, Richter M, Rodrigo-Brenni MC, Shilliday F, Wang P, Storer RI
J Med Chem (2024) 67 pp. 5538-5566 [ DOI: doi:10.1021/acs.jmedchem.3c02136 Pubmed: 38513086 ]
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Complex of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to compound furan 24 (Complex from Homo sapiens)
- 1-[5-[[3,4-bis(chloranyl)-1~{h}-indol-7-yl]sulfamoyl]-3-methyl-furan-2-yl]carbonyl-~{n}-methyl-piperidine-4-carboxamide (513 Da, Ligand)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6sj7
Q-score: 0.46
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nat Chem Biol (2020) 16 pp. 15-23 [ DOI: doi:10.1038/s41589-019-0411-6 Pubmed: 31819272 ]
- Rbm39 (Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 15 (66 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (11 kDa, Protein from Homo sapiens)
- Ddb1-dda1-dcaf15-rbm39 complex (Complex from Homo sapiens)
- Dna damage-binding protein 1 (127 kDa, Protein from Homo sapiens)
- Rna binding protein 39 (9 kDa, Protein from Homo sapiens)
- Ddb1 complex (210 kDa, Complex)
- N~1~-(3-chloro-1h-indol-7-yl)benzene-1,4-disulfonamide (385 Da, Ligand)