Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vby
Q-score: 0.565
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E
Nature (2024) 632 pp. 672-677 [ Pubmed: 39112705 DOI: doi:10.1038/s41586-024-07739-9 ]
- Heptane (100 Da, Ligand)
- Methyl (1r,2s,3s,5s)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (277 Da, Ligand)
- Pentane (72 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sodium-dependent dopamine transporter (63 kDa, Protein from Homo sapiens)
- Pentadecane (212 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Decane (142 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- N-octane (114 Da, Ligand)
- Sodium dependent dopamine transporter in complex with inhibitor (63 kDa, Complex from Homo sapiens)
- Methyl (1s,2r,3s,4r,5r)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9h-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate (459 Da, Ligand)
- Water (18 Da, Ligand)
- Dodecane (170 Da, Ligand)
apo SERT reconstituted in lipid nanodisc in KCl
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7li6
Q-score: 0.436
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Apo state of human serotonin transporter in complex with 15b8 fab in kcl (Complex from Homo sapiens)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7li7
Q-score: 0.364
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dodecane (170 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7li8
Q-score: 0.376
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Dodecane (170 Da, Ligand)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7li9
Q-score: 0.38
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in kcl in presence of serotonin (Complex from Homo sapiens)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7lia
Q-score: 0.498
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in presence of serotonin in nacl (Complex from Homo sapiens)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Decane (142 Da, Ligand)
- Serotonin (176 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Chloride ion (35 Da, Ligand)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mgw
Q-score: 0.362
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antiboty fab light chain (11 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7mly
Q-score: 0.49
Nature (2021) 599 pp. 513-517 [ DOI: doi:10.1038/s41586-021-04022-z Pubmed: 34555840 ]
- Pentane (72 Da, Ligand)
- Hexane (86 Da, Ligand)
- Native heteromeric glycine receptor bound with 3d1 fab (500 kDa, Complex)
- Native heteromeric glycine receptor (Complex from Sus scrofa)
- Pentadecane (212 Da, Ligand)
- Undecane (156 Da, Ligand)
- N-butane (58 Da, Ligand)
- Glycine receptor alpha 1 (51 kDa, Protein from Sus scrofa)
- Decane (142 Da, Ligand)
- Nonane (128 Da, Ligand)
- N-octane (114 Da, Ligand)
- 3d1 fab light chain (11 kDa, Protein from Rattus norvegicus)
- Glycine receptor beta (56 kDa, Protein from Sus scrofa)
- Heptane (100 Da, Ligand)
- 3d1 fab (Complex from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- 3d1 fab heavy chain (12 kDa, Protein from Rattus norvegicus)
- Dodecane (170 Da, Ligand)
Structure of human prestin in the presence of NaCl
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7lgu
Q-score: 0.644
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Structure of human Prestin in nanodisc in the presence of NaCl
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7lgw
Q-score: 0.567
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)