Structure of human K2P13.1 (THIK-1) in lipid nanodisc
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9bsn
Q-score: 0.565
To Be Published
- Homodimer of human k@p13.1 (80 kDa, Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9bws
Q-score: 0.554
To Be Published
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Hexane (86 Da, Ligand)
- Human k2p13.1 with s136p and y273a muatations in lipid nanodisc (Complex from Homo sapiens)
Structure of K2P13.1 (THIK1) S136P in lipid nanodisc
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 9c09
Q-score: 0.576
To Be Published
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Homodimer of human k2p13.1 (thik1) with s136p activating mutation (80 kDa, Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ DOI: doi:10.1038/s41467-023-37106-7 Pubmed: 36914669 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Decane (142 Da, Ligand)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Glycine (75 Da, Ligand)
CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7s8p
Q-score: 0.605
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL
Nature (2021) 600 pp. 170-175 [ Pubmed: 34789874 DOI: doi:10.1038/s41586-021-04126-6 ]
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Mrgprx4-gq ms47134 (Complex from Homo sapiens)
- N-[(1r,3r,5s,7r)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-d-phenylalanine (355 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4 chimera (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7mly
Q-score: 0.49
Nature (2021) 599 pp. 513-517 [ DOI: doi:10.1038/s41586-021-04022-z Pubmed: 34555840 ]
- Pentane (72 Da, Ligand)
- Hexane (86 Da, Ligand)
- Native heteromeric glycine receptor bound with 3d1 fab (500 kDa, Complex)
- Native heteromeric glycine receptor (Complex from Sus scrofa)
- Pentadecane (212 Da, Ligand)
- Undecane (156 Da, Ligand)
- N-butane (58 Da, Ligand)
- Glycine receptor alpha 1 (51 kDa, Protein from Sus scrofa)
- Decane (142 Da, Ligand)
- Nonane (128 Da, Ligand)
- N-octane (114 Da, Ligand)
- 3d1 fab light chain (11 kDa, Protein from Rattus norvegicus)
- Glycine receptor beta (56 kDa, Protein from Sus scrofa)
- Heptane (100 Da, Ligand)
- 3d1 fab (Complex from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- 3d1 fab heavy chain (12 kDa, Protein from Rattus norvegicus)
- Dodecane (170 Da, Ligand)
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 6wu1
Q-score: 0.536
Sauer DB, Trebesch N, Marden JJ, Cocco N, Song J, Koide A, Koide S, Tajkhorshid E, Wang DN
eLife (2020) 9 [ DOI: doi:10.7554/eLife.61350 Pubmed: 32869741 ]
- Hexane (86 Da, Ligand)
- Laindy (Cellular component from Lactobacillus acidophilus)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Dass family sodium-coupled anion symporter (56 kDa, Protein from Lactobacillus acidophilus)
Structure of the LaINDY-malate complex
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 6wu2
Q-score: 0.496
Sauer DB, Trebesch N, Marden JJ, Cocco N, Song J, Koide A, Koide S, Tajkhorshid E, Wang DN
eLife (2020) 9 [ DOI: doi:10.7554/eLife.61350 Pubmed: 32869741 ]
- Hexane (86 Da, Ligand)
- Laindy-malate complex (Cellular component from Lactobacillus acidophilus)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Dass family sodium-coupled anion symporter (56 kDa, Protein from Lactobacillus acidophilus)