CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Dodecane (170 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human EBP complexed with compound 3a
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0s
Q-score: 0.558
Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ, Dere E, Masureel M, Adams DJ, Volgraf M, Braun MG
J Med Chem (2024) 67 pp. 4819-4832 [ Pubmed: 38470227 DOI: doi:10.1021/acs.jmedchem.3c02396 ]
Structural Basis of Human NOX5 Activation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8u86
Q-score: 0.45
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ Pubmed: 38734761 DOI: doi:10.1038/s41467-024-48467-y ]
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Nadph oxidase 5 (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Heme b/c (618 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Structural Basis of Human NOX5 Activation
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 8u7y
Q-score: 0.327
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ Pubmed: 38734761 DOI: doi:10.1038/s41467-024-48467-y ]
- Dodecane (170 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Decane (142 Da, Ligand)
- Nadph oxidase 5 (Complex from Homo sapiens)
- Heme b/c (618 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor apo state
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8oq6
Q-score: 0.559
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- [(2r)-2-heptanoyloxy-3-phosphonooxy-propyl] nonanoate (424 Da, Ligand)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8oq7
Q-score: 0.712
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ Pubmed: 37659407 DOI: doi:10.1016/j.neuron.2023.08.006 ]
- Dodecane (170 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid (161 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8oq8
Q-score: 0.628
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ Pubmed: 37659407 DOI: doi:10.1016/j.neuron.2023.08.006 ]
- Dodecane (170 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- Decane (142 Da, Ligand)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rho1 gabaa receptor (Complex from Homo sapiens)
Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ Pubmed: 36914669 DOI: doi:10.1038/s41467-023-37106-7 ]
- Palmitic acid (256 Da, Ligand)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- Decane (142 Da, Ligand)
- Glycine (75 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8b01
Q-score: 0.539
Davies JS, Currie MJ, North RA, Scalise M, Wright JD, Copping JM, Remus DM, Gulati A, Morado DR, Jamieson SA, Newton-Vesty MC, Abeysekera GS, Ramaswamy S, Friemann R, Wakatsuki S, Allison JR, Indiveri C, Drew D, Mace PD, Dobson RCJ
Nat Commun (2023) 14 pp. 1120-1120 [ Pubmed: 36849793 DOI: doi:10.1038/s41467-023-36590-1 ]
- Tridecane (184 Da, Ligand)
- Siaqm with megabody (Complex)
- Phosphatidylethanolamine (734 Da, Ligand)
- Hexane (86 Da, Ligand)
- Docosane (310 Da, Ligand)
- N-octane (114 Da, Ligand)
- Megabody (Complex from Helicobacter pylori)
- Decane (142 Da, Ligand)
- Putative trap-type c4-dicarboxylate transport system, small permease component (19 kDa, Protein from Photobacterium profundum SS9)
- Siaqm (Complex from Photobacterium profundum)
- Megabody c7hopq (54 kDa, Protein from synthetic construct)
- Putative trap-type c4-dicarboxylate transport system, large permease component (45 kDa, Protein from Photobacterium profundum SS9)
- Sodium ion (22 Da, Ligand)