Structure of human K2P13.1 (THIK-1) in lipid nanodisc
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9bsn
Q-score: 0.565
To Be Published
- Homodimer of human k@p13.1 (80 kDa, Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9bws
Q-score: 0.554
To Be Published
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Hexane (86 Da, Ligand)
- Human k2p13.1 with s136p and y273a muatations in lipid nanodisc (Complex from Homo sapiens)
Structure of K2P13.1 (THIK1) S136P in lipid nanodisc
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 9c09
Q-score: 0.576
To Be Published
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Homodimer of human k2p13.1 (thik1) with s136p activating mutation (80 kDa, Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8w4a
Q-score: 0.619
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Pregnenolone sulfate (396 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
Human EBP complexed with compound 3a
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0s
Q-score: 0.558
Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ, Dere E, Masureel M, Adams DJ, Volgraf M, Braun MG
J Med Chem (2024) 67 pp. 4819-4832 [ Pubmed: 38470227 DOI: doi:10.1021/acs.jmedchem.3c02396 ]
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Hg (Complex from Homo sapiens)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)