CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Pregnenolone sulfate (396 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
particulate methane monooxygenase crosslinked with 2,2,2-trifluoroethanol bound
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8sqw
Q-score: 0.609
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Particulate methane monooxygenase (337 kDa, Complex from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Trifluoroethanol (100 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (27 kDa, Protein from Methylococcus capsulatus)
- Decane (142 Da, Ligand)
- Particulate methane monooxygenase beta subunit (27 kDa, Protein from Methylococcus capsulatus)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase alpha subunit (42 kDa, Protein from Methylococcus capsulatus)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
particulate methane monooxygenase crosslinked with 4,4,4-trifluorobutanol bound
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8sr1
Q-score: 0.551
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (27 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- 4,4,4-trifluorobutan-1-ol (128 Da, Ligand)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase alpha subunit (42 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (27 kDa, Protein from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
particulate methane monooxygenase incubated with 4,4,4-trifluorobutanol
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8sr2
Q-score: 0.452
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) [ ]
- Particulate methane monooxygenase alpha subunit (46 kDa, Protein from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (29 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (28 kDa, Protein from Methylococcus capsulatus str. Bath)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
particulate methane monooxygenase with 2,2,2-trifluoroethanol bound
Resolution: 2.19 Å
EM Method: Single-particle
Fitted PDBs: 8oyi
Q-score: 0.616
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Particulate methane monooxygenase alpha subunit (46 kDa, Protein from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Trifluoroethanol (100 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (29 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (28 kDa, Protein from Methylococcus capsulatus str. Bath)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8dn2
Q-score: 0.417
Nat Commun (2023) 14 pp. 6377-6377 [ Pubmed: 37821459 DOI: doi:10.1038/s41467-023-42051-6 ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Undecane (156 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- N-butane (58 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Nonane (128 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state 2(expanded-open state) (240 kDa, Complex from Homo sapiens)
- Glycine (75 Da, Ligand)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8dn3
Q-score: 0.482
Nat Commun (2023) 14 pp. 6377-6377 [ Pubmed: 37821459 DOI: doi:10.1038/s41467-023-42051-6 ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Undecane (156 Da, Ligand)
- Heteromeric glycine receptor alpha-1 and beta, apo state (240 kDa, Complex from Homo sapiens)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- N-butane (58 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Nonane (128 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8dn5
Q-score: 0.462
Nat Commun (2023) 14 pp. 6377-6377 [ Pubmed: 37821459 DOI: doi:10.1038/s41467-023-42051-6 ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state1 (open state) (240 kDa, Complex from Homo sapiens)
- Undecane (156 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- N-butane (58 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Nonane (128 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Glycine (75 Da, Ligand)