apo SERT reconstituted in lipid nanodisc in KCl
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7li6
Q-score: 0.436
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Apo state of human serotonin transporter in complex with 15b8 fab in kcl (Complex from Homo sapiens)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7li7
Q-score: 0.364
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dodecane (170 Da, Ligand)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7li9
Q-score: 0.38
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in kcl in presence of serotonin (Complex from Homo sapiens)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7lia
Q-score: 0.498
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Pentane (72 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in presence of serotonin in nacl (Complex from Homo sapiens)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Decane (142 Da, Ligand)
- Serotonin (176 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Chloride ion (35 Da, Ligand)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mgw
Q-score: 0.362
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Variable domain of 15b8 antiboty fab light chain (11 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
- Heptane (100 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Chloride ion (35 Da, Ligand)