Structure of human K2P13.1 (THIK-1) in lipid nanodisc
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9bsn
Q-score: 0.565
To Be Published
- Homodimer of human k@p13.1 (80 kDa, Complex from Homo sapiens)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9bws
Q-score: 0.554
To Be Published
- Hexane (86 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- N-octane (114 Da, Ligand)
- Human k2p13.1 with s136p and y273a muatations in lipid nanodisc (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
Structure of K2P13.1 (THIK1) S136P in lipid nanodisc
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 9c09
Q-score: 0.576
To Be Published
- Hexane (86 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- N-octane (114 Da, Ligand)
- Homodimer of human k2p13.1 (thik1) with s136p activating mutation (80 kDa, Complex from Homo sapiens)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Hexadecane (226 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Hexane (86 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Decane (142 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Puerarin (416 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structural Basis of Human NOX5 Activation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8u86
Q-score: 0.45
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ DOI: doi:10.1038/s41467-024-48467-y Pubmed: 38734761 ]
- Nadph oxidase 5 (Complex from Homo sapiens)
- Heme b/c (618 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Decane (142 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
Structural Basis of Human NOX5 Activation
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 8u7y
Q-score: 0.327
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ DOI: doi:10.1038/s41467-024-48467-y Pubmed: 38734761 ]
- Nadph oxidase 5 (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Heme b/c (618 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Decane (142 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
Structure of GABAAR determined by cryoEM at 100 keV
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8pvb
Q-score: 0.486
McMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet MJ, Wilson H, Dickerson JL, Chen S, Cannone G, Lee Y, Hutchings KA, Gittins O, Sobhy MA, Wells T, El-Gomati MM, Dalby J, Meffert M, Schulze-Briese C, Henderson R, Russo CJ
PNAS (2023) 120 pp. e2312905120-e2312905120 [ DOI: doi:10.1073/pnas.2312905120 Pubmed: 38011573 ]
- Hexadecane (226 Da, Ligand)
- Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
- Etomidate (244 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Histamine (111 Da, Ligand)
- Decane (142 Da, Ligand)
- Megabody mb25 (56 kDa, Protein from Lama glama)
Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ DOI: doi:10.1038/s41467-023-37106-7 Pubmed: 36914669 ]
- Palmitic acid (256 Da, Ligand)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8b01
Q-score: 0.539
Davies JS, Currie MJ, North RA, Scalise M, Wright JD, Copping JM, Remus DM, Gulati A, Morado DR, Jamieson SA, Newton-Vesty MC, Abeysekera GS, Ramaswamy S, Friemann R, Wakatsuki S, Allison JR, Indiveri C, Drew D, Mace PD, Dobson RCJ
Nat Commun (2023) 14 pp. 1120-1120 [ Pubmed: 36849793 DOI: doi:10.1038/s41467-023-36590-1 ]
- Hexane (86 Da, Ligand)
- Putative trap-type c4-dicarboxylate transport system, large permease component (45 kDa, Protein from Photobacterium profundum SS9)
- Megabody (Complex from Helicobacter pylori)
- Megabody c7hopq (54 kDa, Protein from synthetic construct)
- N-octane (114 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Siaqm (Complex from Photobacterium profundum)
- Decane (142 Da, Ligand)
- Tridecane (184 Da, Ligand)
- Putative trap-type c4-dicarboxylate transport system, small permease component (19 kDa, Protein from Photobacterium profundum SS9)
- Siaqm with megabody (Complex)
- Docosane (310 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7qn5
Q-score: 0.58
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- Human full-length extrasynaptic alpha4beta3delta gaba(a)r in complex with nanobody nb25 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-4 (61 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Nanobody nb25 (13 kDa, Protein from Lama glama)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid (238 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)