Phosphorylated (E1371Q)CFTR in complex with PKA-C
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9dw9
Q-score: 0.595
Fiedorczuk K, Iordanov I, Mihalyi C, Szollosi A, Csanady L, Chen J
PNAS (2024) 121 pp. e2409049121-e2409049121 [ DOI: doi:10.1073/pnas.2409049121 Pubmed: 39495916 ]
- Undecane (156 Da, Ligand)
- Camp-dependent protein kinase catalytic subunit alpha (40 kDa, Protein from Bos taurus)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- Phosphorylated (e1371q)cftr in complex with pka-c (210 kDa, Complex from Bos taurus)
- Decane (142 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8w4a
Q-score: 0.619
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Pregnenolone sulfate (396 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vby
Q-score: 0.565
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E
Nature (2024) 632 pp. 672-677 [ Pubmed: 39112705 DOI: doi:10.1038/s41586-024-07739-9 ]
- Heptane (100 Da, Ligand)
- Methyl (1r,2s,3s,5s)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (277 Da, Ligand)
- Pentane (72 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sodium-dependent dopamine transporter (63 kDa, Protein from Homo sapiens)
- Pentadecane (212 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Decane (142 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- N-octane (114 Da, Ligand)
- Sodium dependent dopamine transporter in complex with inhibitor (63 kDa, Complex from Homo sapiens)
- Methyl (1s,2r,3s,4r,5r)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9h-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate (459 Da, Ligand)
- Water (18 Da, Ligand)
- Dodecane (170 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Hg (Complex from Homo sapiens)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
To Be Published
- Tetradecane (198 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Hgsnat (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)