Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vby
Q-score: 0.565
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E
Nature (2024) 632 pp. 672-677 [ Pubmed: 39112705 DOI: doi:10.1038/s41586-024-07739-9 ]
- Water (18 Da, Ligand)
- Pentane (72 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Pentadecane (212 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Methyl (1s,2r,3s,4r,5r)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9h-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate (459 Da, Ligand)
- Methyl (1r,2s,3s,5s)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (277 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (63 kDa, Protein from Homo sapiens)
- Sodium dependent dopamine transporter in complex with inhibitor (63 kDa, Complex from Homo sapiens)
CryoEM structure of human rho1 GABAA receptor apo state
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8oq6
Q-score: 0.559
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- [(2r)-2-heptanoyloxy-3-phosphonooxy-propyl] nonanoate (424 Da, Ligand)
- Decane (142 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8oq7
Q-score: 0.712
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid (161 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8oq8
Q-score: 0.628
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Rho1 gabaa receptor (Complex from Homo sapiens)
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ DOI: doi:10.1038/s41467-023-37106-7 Pubmed: 36914669 ]
- Palmitic acid (256 Da, Ligand)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7mly
Q-score: 0.49
Nature (2021) 599 pp. 513-517 [ DOI: doi:10.1038/s41586-021-04022-z Pubmed: 34555840 ]
- Nonane (128 Da, Ligand)
- Hexane (86 Da, Ligand)
- Pentane (72 Da, Ligand)
- N-butane (58 Da, Ligand)
- Dodecane (170 Da, Ligand)
- 3d1 fab heavy chain (12 kDa, Protein from Rattus norvegicus)
- Heptane (100 Da, Ligand)
- 3d1 fab (Complex from Rattus norvegicus)
- Pentadecane (212 Da, Ligand)
- 3d1 fab light chain (11 kDa, Protein from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- N-octane (114 Da, Ligand)
- Glycine receptor beta (56 kDa, Protein from Sus scrofa)
- Decane (142 Da, Ligand)
- Glycine receptor alpha 1 (51 kDa, Protein from Sus scrofa)
- Undecane (156 Da, Ligand)
- Native heteromeric glycine receptor (Complex from Sus scrofa)
- Native heteromeric glycine receptor bound with 3d1 fab (500 kDa, Complex)
Structure of human prestin in the presence of NaCl
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7lgu
Q-score: 0.644
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)
Structure of human Prestin in nanodisc in the presence of NaCl
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7lgw
Q-score: 0.567
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ldd
Q-score: 0.25
Yu J, Rao P, Clark S, Mitra J, Ha T, Gouaux E
Nature (2021) 594 pp. 448-453 [ DOI: doi:10.1038/s41586-021-03540-0 Pubmed: 33981040 ]
- Glutamate receptor (98 kDa, Protein from Mus musculus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Mus musculus)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- 15f1 fab (Complex from Mus musculus)
- Glua1/a2-symmetric-conformation (Complex from Mus musculus)
- Dodecane (170 Da, Ligand)
- Protein cornichon homolog 2 (18 kDa, Protein from Mus musculus)
- Glua1/a2-symmetric-conformation bound to antibody fragments (Complex)
- 11b8 scfv (27 kDa, Protein from Mus musculus)
- Glutamate receptor 1 (101 kDa, Protein from Mus musculus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- 15f1 fab heavy chain (27 kDa, Protein from Mus musculus)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Nonane (128 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- 11b8 scfv (Complex from Mus musculus)
- Decane (142 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 15f1 fab light chain (25 kDa, Protein from Mus musculus)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7lde
Q-score: 0.221
Yu J, Rao P, Clark S, Mitra J, Ha T, Gouaux E
Nature (2021) 594 pp. 448-453 [ DOI: doi:10.1038/s41586-021-03540-0 Pubmed: 33981040 ]
- Glua1/a2-asymmetric-conformation (Complex from Mus musculus)
- Glutamate receptor (98 kDa, Protein from Mus musculus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Mus musculus)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- 15f1 fab (Complex from Mus musculus)
- Dodecane (170 Da, Ligand)
- Protein cornichon homolog 2 (18 kDa, Protein from Mus musculus)
- 11b8 scfv (27 kDa, Protein from Mus musculus)
- Glutamate receptor 1 (101 kDa, Protein from Mus musculus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- 15f1 fab heavy chain (27 kDa, Protein from Mus musculus)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Nonane (128 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- 11b8 scfv (Complex from Mus musculus)
- Decane (142 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 15f1 fab light chain (25 kDa, Protein from Mus musculus)
- Glua1/a2-asymmetric-conformation bound to antibody fragments (Complex)