Phosphorylated (E1371Q)CFTR in complex with PKA-C
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9dw9
Q-score: 0.595
Fiedorczuk K, Iordanov I, Mihalyi C, Szollosi A, Csanady L, Chen J
PNAS (2024) 121 pp. e2409049121-e2409049121 [ DOI: doi:10.1073/pnas.2409049121 Pubmed: 39495916 ]
- Camp-dependent protein kinase catalytic subunit alpha (40 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Phosphorylated (e1371q)cftr in complex with pka-c (210 kDa, Complex from Bos taurus)
- Decane (142 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- Undecane (156 Da, Ligand)
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8w4a
Q-score: 0.619
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ Pubmed: 38769387 DOI: doi:10.1038/s41594-024-01315-5 ]
- Hexadecane (226 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Hexadecane (226 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Hexane (86 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Decane (142 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Puerarin (416 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ Pubmed: 38769387 DOI: doi:10.1038/s41594-024-01315-5 ]
- Hexadecane (226 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Hg (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ Pubmed: 38769387 DOI: doi:10.1038/s41594-024-01315-5 ]
- Hexadecane (226 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Decane (142 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ Pubmed: 38769387 DOI: doi:10.1038/s41594-024-01315-5 ]
- Hexadecane (226 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Decane (142 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
To Be Published
- Hexadecane (226 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
Structural Basis of Human NOX5 Activation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8u86
Q-score: 0.45
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ DOI: doi:10.1038/s41467-024-48467-y Pubmed: 38734761 ]
- Nadph oxidase 5 (Complex from Homo sapiens)
- Heme b/c (618 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Decane (142 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
Structural Basis of Human NOX5 Activation
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 8u7y
Q-score: 0.327
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun (2024) 15 pp. 3994-3994 [ DOI: doi:10.1038/s41467-024-48467-y Pubmed: 38734761 ]
- Nadph oxidase 5 (Complex from Homo sapiens)
- Dodecane (170 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Heme b/c (618 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Decane (142 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Nadph oxidase 5 (82 kDa, Protein from Homo sapiens)
Structure of GABAAR determined by cryoEM at 100 keV
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8pvb
Q-score: 0.486
McMullan G, Naydenova K, Mihaylov D, Yamashita K, Peet MJ, Wilson H, Dickerson JL, Chen S, Cannone G, Lee Y, Hutchings KA, Gittins O, Sobhy MA, Wells T, El-Gomati MM, Dalby J, Meffert M, Schulze-Briese C, Henderson R, Russo CJ
PNAS (2023) 120 pp. e2312905120-e2312905120 [ DOI: doi:10.1073/pnas.2312905120 Pubmed: 38011573 ]
- Hexadecane (226 Da, Ligand)
- Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
- Etomidate (244 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Histamine (111 Da, Ligand)
- Decane (142 Da, Ligand)
- Megabody mb25 (56 kDa, Protein from Lama glama)