Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8fe1
Q-score: 0.527
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S
Nat Commun (2023) 14 pp. 1363-1363 [ DOI: doi:10.1038/s41467-023-37106-7 Pubmed: 36914669 ]
- Palmitic acid (256 Da, Ligand)
- Glycine receptor subunit alphaz1 (52 kDa, Protein from Danio rerio)
- Zebrafish alpha1 betab heteromeric glycine receptor (250 kDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- 1,2-dimyristoyl-sn-glycero-3-phosphocholine (678 Da, Ligand)
- Decane (142 Da, Ligand)
- Glycine receptor beta subunit 2 (65 kDa, Protein from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-l-arabino-hexopyranosyl)-3-o-methyl-alpha-l-arabino-hexopyranoside (875 Da, Ligand)
apo SERT reconstituted in lipid nanodisc in KCl
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7li6
Q-score: 0.436
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Hexadecane (226 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Decane (142 Da, Ligand)
- Apo state of human serotonin transporter in complex with 15b8 fab in kcl (Complex from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7li7
Q-score: 0.364
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Pentane (72 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Heptane (100 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Decane (142 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7li8
Q-score: 0.376
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Hexadecane (226 Da, Ligand)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Pentane (72 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Decane (142 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in KCl
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7li9
Q-score: 0.38
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Pentane (72 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Decane (142 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in kcl in presence of serotonin (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7lia
Q-score: 0.498
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Pentane (72 Da, Ligand)
- Human serotonin transporter in complex with 15b8 fab in presence of serotonin in nacl (Complex from Homo sapiens)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Variable domain of 15b8 antibody fab light chain (11 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Decane (142 Da, Ligand)
- Cholesterol (386 Da, Ligand)
5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mgw
Q-score: 0.362
Sci Adv (2021) 7 pp. eabl3857-eabl3857 [ Pubmed: 34851672 DOI: doi:10.1126/sciadv.abl3857 ]
- Serotonin (176 Da, Ligand)
- Pentane (72 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Variable domain of 15b8 antibody fab heavy chain (12 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (60 kDa, Protein from Homo sapiens)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Decane (142 Da, Ligand)
- Apo human serotonin transporter in complex with 15b8 fab in nacl (Complex from Homo sapiens)
- Variable domain of 15b8 antiboty fab light chain (11 kDa, Protein from Mus musculus)
Cryo-EM reveals partially and fully assembled native glycine receptors,heteromeric pentamer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7mly
Q-score: 0.49
Nature (2021) 599 pp. 513-517 [ DOI: doi:10.1038/s41586-021-04022-z Pubmed: 34555840 ]
- Nonane (128 Da, Ligand)
- Hexane (86 Da, Ligand)
- Pentane (72 Da, Ligand)
- N-butane (58 Da, Ligand)
- Dodecane (170 Da, Ligand)
- 3d1 fab heavy chain (12 kDa, Protein from Rattus norvegicus)
- Heptane (100 Da, Ligand)
- 3d1 fab (Complex from Rattus norvegicus)
- Pentadecane (212 Da, Ligand)
- 3d1 fab light chain (11 kDa, Protein from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- N-octane (114 Da, Ligand)
- Glycine receptor beta (56 kDa, Protein from Sus scrofa)
- Decane (142 Da, Ligand)
- Glycine receptor alpha 1 (51 kDa, Protein from Sus scrofa)
- Undecane (156 Da, Ligand)
- Native heteromeric glycine receptor (Complex from Sus scrofa)
- Native heteromeric glycine receptor bound with 3d1 fab (500 kDa, Complex)
Structure of human prestin in the presence of NaCl
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7lgu
Q-score: 0.644
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)
Structure of human Prestin in nanodisc in the presence of NaCl
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7lgw
Q-score: 0.567
Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell (2021) 184 pp. 4669- [ Pubmed: 34390643 DOI: doi:10.1016/j.cell.2021.07.034 ]
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Protein structure bound with substrates and lipids (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Prestin (82 kDa, Protein from Homo sapiens)