Phosphorylated (E1371Q)CFTR in complex with PKA-C
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9dw9
Q-score: 0.595
Fiedorczuk K, Iordanov I, Mihalyi C, Szollosi A, Csanady L, Chen J
PNAS (2024) 121 pp. e2409049121-e2409049121 [ DOI: doi:10.1073/pnas.2409049121 Pubmed: 39495916 ]
- Magnesium ion (24 Da, Ligand)
- Camp-dependent protein kinase catalytic subunit alpha (40 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Decane (142 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Undecane (156 Da, Ligand)
- Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)
- Phosphorylated (e1371q)cftr in complex with pka-c (210 kDa, Complex from Bos taurus)
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8w4a
Q-score: 0.619
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ Pubmed: 38769387 DOI: doi:10.1038/s41594-024-01315-5 ]
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heptane (100 Da, Ligand)
- Dodecane (170 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- ~{n}-[(2~{s},3~{r},4~{r},5~{s},6~{r})-6-(hydroxymethyl)-2-[[(2~{r},4~{r})-4-methyl-2-oxidanyl-3,4-dihydro-2~{h}-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]ethanamide (383 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- Tetradecane (198 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Dodecane (170 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- Water (18 Da, Ligand)
- Hexane (86 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vby
Q-score: 0.565
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E
Nature (2024) 632 pp. 672-677 [ Pubmed: 39112705 DOI: doi:10.1038/s41586-024-07739-9 ]
- Dodecane (170 Da, Ligand)
- Water (18 Da, Ligand)
- Methyl (1r,2s,3s,5s)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (277 Da, Ligand)
- Methyl (1s,2r,3s,4r,5r)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9h-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate (459 Da, Ligand)
- Pentane (72 Da, Ligand)
- Decane (142 Da, Ligand)
- Sodium dependent dopamine transporter in complex with inhibitor (63 kDa, Complex from Homo sapiens)
- Pentadecane (212 Da, Ligand)
- N-octane (114 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (63 kDa, Protein from Homo sapiens)
- Heptane (100 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Human EBP complexed with compound 3a
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0s
Q-score: 0.558
Dorel R, Sun D, Carruthers N, Castanedo GM, Ung PM, Factor DC, Li T, Baumann H, Janota D, Pang J, Salphati L, Meklemburg R, Korman AJ, Harper HE, Stubblefield S, Payandeh J, McHugh D, Lang BT, Tesar PJ, Dere E, Masureel M, Adams DJ, Volgraf M, Braun MG
J Med Chem (2024) 67 pp. 4819-4832 [ Pubmed: 38470227 DOI: doi:10.1021/acs.jmedchem.3c02396 ]
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- N-octane (114 Da, Ligand)
- Hg (Complex from Homo sapiens)
- Tetradecane (198 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Decane (142 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
Xu R, Ning Y, Ren F, Gu C, Zhu Z, Pan X, Pshezhetsky AV, Ge J, Yu J
Nat Struct Mol Biol (2024) 31 pp. 1502-1508 [ DOI: doi:10.1038/s41594-024-01315-5 Pubmed: 38769387 ]
- Dodecane (170 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Hgsnat (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (77 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)