particulate methane monooxygenase crosslinked with 2,2,2-trifluoroethanol bound
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8sqw
Q-score: 0.609
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Particulate methane monooxygenase (337 kDa, Complex from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Trifluoroethanol (100 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (27 kDa, Protein from Methylococcus capsulatus)
- Decane (142 Da, Ligand)
- Particulate methane monooxygenase beta subunit (27 kDa, Protein from Methylococcus capsulatus)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase alpha subunit (42 kDa, Protein from Methylococcus capsulatus)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
particulate methane monooxygenase crosslinked with 4,4,4-trifluorobutanol bound
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8sr1
Q-score: 0.551
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (27 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- 4,4,4-trifluorobutan-1-ol (128 Da, Ligand)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase alpha subunit (42 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (27 kDa, Protein from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
particulate methane monooxygenase incubated with 4,4,4-trifluorobutanol
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8sr2
Q-score: 0.452
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) [ ]
- Particulate methane monooxygenase alpha subunit (46 kDa, Protein from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (29 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (28 kDa, Protein from Methylococcus capsulatus str. Bath)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
particulate methane monooxygenase with 2,2,2-trifluoroethanol bound
Resolution: 2.19 Å
EM Method: Single-particle
Fitted PDBs: 8oyi
Q-score: 0.616
Tucci FJ, Jodts RJ, Hoffman BM, Rosenzweig AC
Nat Catal (2023) 6 pp. 1194-1204 [ DOI: doi:10.1038/s41929-023-01051-x Pubmed: 38187819 ]
- Particulate methane monooxygenase alpha subunit (46 kDa, Protein from Methylococcus capsulatus str. Bath)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Trifluoroethanol (100 Da, Ligand)
- Ammonia monooxygenase/methane monooxygenase, subunit c family protein (29 kDa, Protein from Methylococcus capsulatus str. Bath)
- Particulate methane monooxygenase beta subunit (28 kDa, Protein from Methylococcus capsulatus str. Bath)
- Decane (142 Da, Ligand)
- 1,2-dihexanoyl-sn-glycero-3-phosphocholine (454 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Particulate methane monooxygenase (337 MDa, Complex from Methylococcus capsulatus str. Bath)
- 1,2-didecanoyl-sn-glycero-3-phosphocholine (566 Da, Ligand)
- Water (18 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor apo state
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8oq6
Q-score: 0.559
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- [(2r)-2-heptanoyloxy-3-phosphonooxy-propyl] nonanoate (424 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8oq7
Q-score: 0.712
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid (161 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Human rho1 gabaa receptor (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Dodecane (170 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8oq8
Q-score: 0.628
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450- [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rho1 gabaa receptor (Complex from Homo sapiens)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Water (18 Da, Ligand)
- Dodecane (170 Da, Ligand)