Herbine K, Nayak AR, Temiakov D
Nat Commun (2024) 15 pp. 7134-7134 [ DOI: doi:10.1038/s41467-024-50817-9 Pubmed: 39164235 ]
- Template strand dna (ts31mt) (10 kDa, DNA from synthetic construct)
- Diphosphomethylphosphonic acid adenosyl ester (505 Da, Ligand)
- Non-template strand dna (nt27mt) (10 kDa, DNA from synthetic construct)
- Rna (rna14mt) (4 kDa, RNA from synthetic construct)
- Dna-directed rna polymerase, mitochondrial (127 kDa, Protein from Homo sapiens)
- Cognate substrate bound in the entry site (es) of human mitochondrial transcription elongation complex (227 kDa, Complex from Homo sapiens)
- Transcription elongation factor, mitochondrial (27 kDa, Protein from Homo sapiens)
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8u8v
Q-score: 0.405
Herbine K, Nayak AR, Temiakov D
Nat Commun (2024) 15 pp. 7134-7134 [ DOI: doi:10.1038/s41467-024-50817-9 Pubmed: 39164235 ]
- Transcription elongation factor, mitochondrial (27 kDa, Protein from Homo sapiens)
- Rna (rna14mt) (4 kDa, RNA from synthetic construct)
- Non-template strand dna (nt27mt) (10 kDa, DNA from synthetic construct)
- Substrate atp bound to insertion site (is) of human mitochondrial transcription elongation complex (227 kDa, Complex from Homo sapiens)
- Diphosphomethylphosphonic acid adenosyl ester (505 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase, mitochondrial (127 kDa, Protein from Homo sapiens)
- Template strand dna (ts31mt) (10 kDa, DNA from synthetic construct)
Cryo-EM Structure of the TEFM-bound Human Mitochondrial Transcription Substrate Rejection Complex
Herbine K, Nayak AR, Temiakov D
Nat Commun (2024) 15 pp. 7134-7134 [ DOI: doi:10.1038/s41467-024-50817-9 Pubmed: 39164235 ]
- Transcription elongation factor, mitochondrial (27 kDa, Protein from Homo sapiens)
- Rna (rna14mt) (4 kDa, RNA from synthetic construct)
- Template strand dna (ts31mt_+1a) (10 kDa, DNA from synthetic construct)
- Non-template strand dna (nt27mt_+1t) (10 kDa, DNA from synthetic construct)
- Structure of the transcription elongation complex of human mitochondrial polymerase with the closed conformation of the fingers domain (227 kDa, Complex from Homo sapiens)
- Dna-directed rna polymerase, mitochondrial (127 kDa, Protein from Homo sapiens)
Herbine K, Nayak AR, Temiakov D
Nat Commun (2024) 15 pp. 7134-7134 [ DOI: doi:10.1038/s41467-024-50817-9 Pubmed: 39164235 ]
- Diphosphomethylphosphonic acid adenosyl ester (505 Da, Ligand)
- Non-cognate substrate bound in the entry site (es) of human mitochondrial transcription elongation complex (227 kDa, Complex from Homo sapiens)
- Template strand dna (ts31mt_+1a) (10 kDa, DNA from synthetic construct)
- Rna (rna14mt) (4 kDa, RNA from synthetic construct)
- Dna-directed rna polymerase, mitochondrial (127 kDa, Protein from Homo sapiens)
- Transcription elongation factor, mitochondrial (27 kDa, Protein from Homo sapiens)
- Non-template strand dna (nt27mt_+1t) (10 kDa, DNA from synthetic construct)