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sample_name:"DNA (TS)" AND author_orcid:"0009-0001-1360-2778"
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Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (engaged state)

Release date: Jan. 24, 2024
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tug
Q-score: 0.382

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (open state)

Release date: Jan. 24, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tvp
Q-score: 0.357

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of CPD stalled 10-subunit Pol II in complex with Rad26

Release date: Jan. 24, 2024
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8tvq
Q-score: 0.247

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of backtracked Pol II in complex with Rad26

Release date: Jan. 24, 2024
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8tvs
Q-score: 0.305

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of backtracked Pol II

Release date: Jan. 24, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tvv
Q-score: 0.37

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ DOI: doi:10.1073/pnas.2314245121 Pubmed: 38194460 ]

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Cryo-EM structure of CPD-stalled Pol II (conformation 1)

Release date: Jan. 24, 2024
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tvw
Q-score: 0.385

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of CPD-stalled Pol II (Conformation 2)

Release date: Jan. 24, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tvx
Q-score: 0.359

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ Pubmed: 38194460 DOI: doi:10.1073/pnas.2314245121 ]

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Cryo-EM structure of CPD lesion containing RNA Polymerase II elongation complex with Rad26 and Elf1 (closed state)

Release date: Jan. 24, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tvy
Q-score: 0.433

Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE

PNAS (2024) 121 pp. e2314245121-e2314245121 [ DOI: doi:10.1073/pnas.2314245121 Pubmed: 38194460 ]

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Ternary complex of RNA Pol II, transcription scaffold and Rad26

Release date: Nov. 22, 2017
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 5vvr
Q-score: 0.174

Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D

Nature (2017) 551 pp. 653-657 [ DOI: doi:10.1038/nature24658 Pubmed: 29168508 ]

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RNA pol II elongation complex

Release date: Nov. 22, 2017
Resolution: 6.4 Å
EM Method: Single-particle
Fitted PDBs: 5vvs
Q-score: 0.184

Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D

Nature (2017) 551 pp. 653-657 [ DOI: doi:10.1038/nature24658 Pubmed: 29168508 ]

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