Cryo-EM structure of DDB1deltaB-DDA1-DCAF5
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8tl6
Q-score: 0.598
Radko-Juettner S, Yue H, Myers JA, Carter RD, Robertson AN, Mittal P, Zhu Z, Hansen BS, Donovan KA, Hunkeler M, Rosikiewicz W, Wu Z, McReynolds MG, Roy Burman SS, Schmoker AM, Mageed N, Brown SA, Mobley RJ, Partridge JF, Stewart EA, Pruett-Miller SM, Nabet B, Peng J, Gray NS, Fischer ES, Roberts CWM
Nature (2024) 628 pp. 442-449 [ DOI: doi:10.1038/s41586-024-07250-1 Pubmed: 38538798 ]
- Complex of ddb1deltab-dda1-dcaf5 (220 kDa, Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 5 (108 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (14 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (96 kDa, Protein from Homo sapiens)
Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8g46
Q-score: 0.643
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Lumpkin R, Sandoval B, Jin CY, Ficarro SB, Wang MY, Xu S, Groendyke BJ, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Marto JA, Qi J, Nowak RP, Donovan KA, Slabicki M, Gray NS, Fischer ES, Ebert BL
bioRxiv (2023) [ DOI: doi:10.1101/2023.02.14.528208 Pubmed: 36824856 ]
- Zinc ion (65 Da, Ligand)
- Ternary complex of cullin ring e3 ubiquitin ligase substrate receptor arm (ddb1deltab-dda1-dcaf16) in compound-induced complex with bromodomain 2 of brd4 (148 kDa, Complex from Homo sapiens)
- Dna damage-binding protein 1 (96 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (12 kDa, Protein from Homo sapiens)
- Bromodomain-containing protein 4 (14 kDa, Protein from Homo sapiens)
- Ddb1- and cul4-associated factor 16 (24 kDa, Protein from Homo sapiens)
- Tert-butyl [(6s,10p)-4-{4-[(ethanesulfonyl)amino]phenyl}-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate (529 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of DDB1dB-DCAF15-DDA1 bound to E7820 and RBM39
Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES
Nat Chem Biol (2020) 16 pp. 7-14 [ DOI: doi:10.1038/s41589-019-0378-3 Pubmed: 31686031 ]
- Det1 and ddb1 associated 1 (Protein from Homo sapiens)
- Complex of ddb1-dcaf15-dda1 bound to e7820 and the second rrm of rbm39 (193 kDa, Complex from Homo sapiens)
- Ddb1 and cul4 associated factor 15 (Protein from Homo sapiens)
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Rna binding motif protein 39 (Protein from Homo sapiens)
Cryo-EM structure of DDB1-DCAF15 bound to E7820 and the second RRM of RBM39
Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES
Nat Chem Biol (2020) 16 pp. 7-14 [ DOI: doi:10.1038/s41589-019-0378-3 Pubmed: 31686031 ]