Llerena Schiffmacher DA, Lee SH, Kliza KW, Theil AF, Akita M, Helfricht A, Bezstarosti K, Gonzalo-Hansen C, van Attikum H, Verlaan-de Vries M, Vertegaal ACO, Hoeijmakers JHJ, Marteijn JA, Lans H, Demmers JAA, Vermeulen M, Sixma TK, Ogi T, Vermeulen W, Pines A
Nat Commun (2024) 15 pp. 6374-6374 [ DOI: doi:10.1038/s41467-024-50584-7 Pubmed: 39075067 ]
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Dna excision repair protein ercc-8 (Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (Protein from Homo sapiens)
- Ternary complex of csa-ddb1-dda1 (190 kDa, Complex from Homo sapiens)
Focused map for CSA-DDB1-DDA1 (map 2)
Llerena Schiffmacher DA, Lee SH, Kliza KW, Theil AF, Akita M, Helfricht A, Bezstarosti K, Gonzalo-Hansen C, van Attikum H, Verlaan-de Vries M, Vertegaal ACO, Hoeijmakers JHJ, Marteijn JA, Lans H, Demmers JAA, Vermeulen M, Sixma TK, Ogi T, Vermeulen W, Pines A
Nat Commun (2024) 15 pp. 6374-6374 [ DOI: doi:10.1038/s41467-024-50584-7 Pubmed: 39075067 ]
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Dna excision repair protein ercc-8 (Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (Protein from Homo sapiens)
- Ternary complex of csa-ddb1-dda1 (190 kDa, Complex from Homo sapiens)
Focused map for UVSSA(VHS)-CSA-DDB1(BPA/BPC)-DDA1
Llerena Schiffmacher DA, Lee SH, Kliza KW, Theil AF, Akita M, Helfricht A, Bezstarosti K, Gonzalo-Hansen C, van Attikum H, Verlaan-de Vries M, Vertegaal ACO, Hoeijmakers JHJ, Marteijn JA, Lans H, Demmers JAA, Vermeulen M, Sixma TK, Ogi T, Vermeulen W, Pines A
Nat Commun (2024) 15 pp. 6374-6374 [ DOI: doi:10.1038/s41467-024-50584-7 Pubmed: 39075067 ]
- Dna excision repair protein ercc-8 (Protein from Homo sapiens)
- Ternary complex of uvssa(vhs)-csa-ddb1(bpa/bpc)-dda1 (170 kDa, Complex from Homo sapiens)
- Uv-stimulated scaffold protein a (Protein from Homo sapiens)
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (Protein from Homo sapiens)
CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1
To Be Published
- Uv-stimulated scaffold protein a (82 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (129 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (16 kDa, Protein from Homo sapiens)
- Dna excision repair protein ercc-8 (45 kDa, Protein from Homo sapiens)
- Ternary complex of uvssa(vhs)-csa-ddb1-dda1 (210 kDa, Complex from Homo sapiens)
Consensus map of UVSSA(VHS)-CSA-DDB1-DDA1
Llerena Schiffmacher DA, Lee SH, Kliza KW, Theil AF, Akita M, Helfricht A, Bezstarosti K, Gonzalo-Hansen C, van Attikum H, Verlaan-de Vries M, Vertegaal ACO, Hoeijmakers JHJ, Marteijn JA, Lans H, Demmers JAA, Vermeulen M, Sixma TK, Ogi T, Vermeulen W, Pines A
Nat Commun (2024) 15 pp. 6374-6374 [ DOI: doi:10.1038/s41467-024-50584-7 Pubmed: 39075067 ]
- Dna excision repair protein ercc-8 (Protein from Homo sapiens)
- Uv-stimulated scaffold protein a (Protein from Homo sapiens)
- Dna damage-binding protein 1 (Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (Protein from Homo sapiens)
- Ternary complex of uvssa(vhs)-csa-ddb1-dda1 (210 kDa, Complex from Homo sapiens)
Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8tnq
Q-score: 0.591
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR
Science (2024) 383 pp. eadk4422-eadk4422 [ DOI: doi:10.1126/science.adk4422 Pubmed: 38484051 ]
- Zinc ion (65 Da, Ligand)
- Protein cereblon (55 kDa, Protein from Homo sapiens)
- 2-[(3s)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1h-isoindole-1,3(2h)-dione (343 Da, Ligand)
- Ternary complex of ddb1db:crbn:pt-179 with sd40 (201 kDa, Complex)
- Dna damage-binding protein 1 (96 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,sd40 (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8tnr
Q-score: 0.561
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR
Science (2024) 383 pp. eadk4422-eadk4422 [ DOI: doi:10.1126/science.adk4422 Pubmed: 38484051 ]
- Zinc ion (65 Da, Ligand)
- Protein cereblon (55 kDa, Protein from Homo sapiens)
- 2-[(3s)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1h-isoindole-1,3(2h)-dione (343 Da, Ligand)
- Ternary complex of ddb1db:crbn:pt-179 with sd40 (201 kDa, Complex)
- Dna damage-binding protein 1 (96 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,sd40 (50 kDa, Protein from Homo sapiens)
Map from local refinement (focused on CRBN) of DDB1dB:CRBN:PT-179:SD40, conformation 1
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR
Science (2024) 383 pp. eadk4422-eadk4422 [ DOI: doi:10.1126/science.adk4422 Pubmed: 38484051 ]
Map from local refinement (focused on CRBN) of DDB1dB:CRBN:PT-179:SD40, conformation 2
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR
Science (2024) 383 pp. eadk4422-eadk4422 [ DOI: doi:10.1126/science.adk4422 Pubmed: 38484051 ]
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 7zn7
Q-score: 0.395
Le-Trilling VTK, Banchenko S, Paydar D, Leipe PM, Binting L, Lauer S, Graziadei A, Klingen R, Gotthold C, Burger J, Bracht T, Sitek B, Jan Lebbink R, Malyshkina A, Mielke T, Rappsilber J, Spahn CM, Voigt S, Trilling M, Schwefel D
EMBO J (2023) 42 pp. e112351-e112351 [ Pubmed: 36762436 DOI: doi:10.15252/embj.2022112351 ]
- E27 (Complex from Murid betaherpesvirus 8)
- Zinc ion (65 Da, Ligand)
- Signal transducer and activator of transcription (Complex from Rattus norvegicus)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
- B27a (76 kDa, Protein from Murid betaherpesvirus 8)
- Signal transducer and activator of transcription (97 kDa, Protein from Rattus norvegicus)
- Dna damage-binding protein 1 (Complex from Homo sapiens)
- Ternary complex of rcmv-e e27 with human ddb1 (deltabpb) and rat stat2 (100 kDa, Complex from Murid betaherpesvirus 8)